Rome2Rio

How to get fromIsla Mujeres to Santiago de Cubaby ferry, bus, plane, or shuttle

Find Transport to Santiago de Cuba

See all options

There are 3 ways to get from Isla Mujeres to Santiago de Cuba by ferry, bus, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Ferry, bus, ferry to Cozumel International Airport, fly to Antonio Maceo International Airport

    best
    1. Take the ferry from Isla Mujeres to Playa Tortugasferry ferry
    2. Take the bus from Terminal de Autobuses ADO Cancún to Playa del Carmen Terminal Turísticabus bus
    3. Take the ferry from Playa del Carmen to Cozumelferry ferry
    4. Fly from Cozumel International Airport (CZM) to Antonio Maceo International Airport (SCU)plane plane CZM - SCU
    25h 52m
    $205–887

  2. Ferry to Cancún International Airport, fly to Antonio Maceo International Airport

    1. Take the ferry from Isla Mujeres to Playa Tortugasferry ferry
    2. Fly from Cancún International Airport (CUN) to Antonio Maceo International Airport (SCU)plane plane CUN - SCU
    11h 29m
    $358–1,176

  3. Ferry, bus, ferry to Cozumel International Airport, fly to Frank País International Airport, shuttle

    1. Take the ferry from Isla Mujeres to Playa Tortugasferry ferry
    2. Take the bus from Terminal de Autobuses ADO Cancún to Playa del Carmen Terminal Turísticabus bus
    3. Take the ferry from Playa del Carmen to Cozumelferry ferry
    4. Fly from Cozumel International Airport (CZM) to Frank País International Airport (HOG)plane plane CZM - HOG
    5. Take a shuttle bus from Hotel Pernik Holguin to Melia Santiago de Cubashuttle bus
    30h
    $205–872

Cozumel International Airport (CZM) to Antonio Maceo International Airport (SCU) flights

Calendar18Weekly Planes
Duration19hAverage Duration
Ticket$172Cheapest Price
See schedules

Questions & Answers

Map of how to get from Isla Mujeres to Santiago de Cuba.ExpandLaunch map view
  • Distance: 1,277.1 km
  • Duration: 25h 52m

What companies run services between Isla Mujeres, Mexico and Santiago de Cuba?

There is no direct connection from Isla Mujeres to Santiago de Cuba. However, you can take the ferry to Playa Tortugas, walk to Playa Tortugas R, take the bus to Famsa, walk to Terminal de Autobuses ADO Cancún, take the bus to Playa del Carmen Terminal Turística, walk to Playa del Carmen, take the ferry to Cozumel, walk to Cozumel, take the shuttle to Cozumel Airport, walk to Cozumel International Airport (CZM) airport, fly to Antonio Maceo International Airport (SCU), walk to Santiago Airport, then take the bus to La Colonia. Alternatively, you can take the ferry to Playa Tortugas, walk to Playa Tortugas, take the shuttle to Aeropuerto Internacional de Cancún Terminal 2, walk to Cancún International Airport (CUN) airport, fly to Antonio Maceo International Airport (SCU), walk to Santiago Airport, then take the bus to La Colonia.

Airlines
Bus operators
Ferry operators

Want to know more about travelling around the world?

Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Getting to Rome from the airport, Travelling Croatia’s Dalmatian Coast by boat, bus, car and train, and What are the different types of Renfe trains in Spain? - to help you get the most out of your next trip.