There are 11 ways to get from Ispra to Karlsruhe by train (Trenitalia), bus, car, train, plane, or night train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train via Basel
best- Take the train from Lugano to Basel SBBtrain Ic21 / ...
- Take the train from Basel SBB to Karlsruhe Hauptbahnhoftrain 12 / ...
8h€62–204Bus
cheapest- Take the bus from Como Grandate to Karlsruhe central train stationbus FlixBus 024
12h 46m€46–78Drive 490.5 km
- Drive from Ispra to Karlsruhecar 490.5 km
5h 9m€80–115Train to Milano Malpensa Airport, fly to Stuttgart Airport, train
- Take the train from Varese to Malpensa Aeroporto T1train
- Fly from Milano Malpensa Airport (MXP) to Stuttgart Airport (STR)plane MXP - STR
- Take the train from Stuttgart Hbf to Karlsruhe Hbftrain
6h 20m€89–287Train (Trenitalia)
- Take the train from Lugano to Karlsruhe Hbftrain Ec
8h 4m€102–159Train, night train
- Take the train from Varese to Castionetrain S50
- Take the train from Castione-Arbedo to Zürich HBtrain
- Take the nighttrain from Zuerich Hb to Karlsruhe Hbfnighttrain Nj
10h 49m€88–191Train to Milan Linate Airport, fly to Stuttgart Airport, train
- Take the train from Gavirate to Milano Cadornatrain
- Fly from Milan Linate Airport (LIN) to Stuttgart Airport (STR)plane LIN - STR
- Take the train from Stuttgart Hbf to Karlsruhe Hbftrain
6h 54m€136–379Train to Milano Malpensa Airport, fly to Frankfurt, train
- Take the train from Varese to Malpensa Aeroporto T1train
- Fly from Milano Malpensa Airport (MXP) to Frankfurt (FRA)plane MXP - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain
7h 2m€77–243Train to Milano Malpensa Airport, fly to Zurich Airport, train
- Take the train from Varese to Malpensa Aeroporto T1train
- Fly from Milano Malpensa Airport (MXP) to Zurich Airport (ZRH)plane MXP - ZRH
- Take the train from Zürich HB to Basel SBBtrain
- Take the train from Basel SBB to Karlsruhe Hauptbahnhoftrain
7h 29m€142–347Train to Zurich Airport, fly to Stuttgart Airport, train
- Take the train from Lugano to Zuerich Hbtrain
- Fly from Zurich Airport (ZRH) to Stuttgart Airport (STR)plane ZRH - STR
- Take the train from Stuttgart Hbf to Karlsruhe Hbftrain
8h 7m€176–482Train to Milan Linate Airport, fly to Frankfurt, train
- Take the train from Gavirate to Milano Cadornatrain
- Fly from Milan Linate Airport (LIN) to Frankfurt (FRA)plane LIN - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain
7h 45m€59–215
Ispra to Karlsruhe by bus and train
Comparing Your Travel Options
The cheapest way to get from Ispra to Karlsruhe is to bus which costs €45 - €80 and takes 12h 46m.
The fastest way to get from Ispra to Karlsruhe is to drive which takes 5h 9m and costs €75 - €120.
No, there is no direct bus from Ispra to Karlsruhe station. However, there are services departing from Ispra, Mazzini/Roma,distributore and arriving at Karlsruhe central train station via Varese - Stazione FNM and Como Grandate. The journey, including transfers, takes approximately 12h 46m.
No, there is no direct train from Ispra to Karlsruhe. However, there are services departing from Varese and arriving at Karlsruhe Hauptbahnhof via Lugano and Basel SBB. The journey, including transfers, takes approximately 8h.
The distance between Ispra and Karlsruhe is 508 km. The road distance is 490.5 km.
The best way to get from Ispra to Karlsruhe without a car is to train via Basel which takes 8h and costs €60 - €210.
It takes approximately 8h to get from Ispra to Karlsruhe, including transfers.
Ispra to Karlsruhe bus services, operated by FlixBus, depart from Como Grandate station.
Ispra to Karlsruhe train services, operated by Swiss Federal Railways (SBB CFF FFS), depart from Lugano station.
The best way to get from Ispra to Karlsruhe is to train via Basel which takes 8h and costs €60 - €210. Alternatively, you can bus, which costs €45 - €80 and takes 12h 46m.
What companies run services between Ispra, Italy and Karlsruhe, Germany?
You can take a bus from Ispra, Mazzini/Roma,distributore to Karlsruhe Hauptbahnhof via Varese, Morosini,Stazione FS FN, Varese, Lugano, and Basel SBB in around 8h. Alternatively, FlixBus operates a bus from Como Grandate to Karlsruhe central train station 5 times a week. Tickets cost €40–70 and the journey takes 9h 5m.
- Website
- lufthansa.com
Flights from Milan Linate Airport to Stuttgart Airport via Munich
- Ave. Duration
- 2h 55m
- When
- Every day
- Estimated price
- €130–310
Flights from Milano Malpensa Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–340
Flights from Milano Malpensa Airport to Frankfurt via Munich
- Ave. Duration
- 3h 5m
- When
- Every day
- Estimated price
- €110–370
Flights from Zurich Airport to Stuttgart Airport
- Ave. Duration
- 45 min
- When
- Every day
- Estimated price
- €65–550
Flights from Milan Linate Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €50–400
Flights from Milan Linate Airport to Frankfurt via Munich
- Ave. Duration
- 3h 21m
- When
- Every day
- Estimated price
- €50–350
- Website
- swiss.com
Flights from Milano Malpensa Airport to Stuttgart Airport via Zurich Airport
- Ave. Duration
- 2h 45m
- When
- Tuesday to Sunday
- Estimated price
- €80–300
Flights from Milano Malpensa Airport to Frankfurt via Zurich Airport
- Ave. Duration
- 3h 20m
- When
- Monday to Saturday
- Estimated price
- €65–250
Flights from Milano Malpensa Airport to Zurich Airport
- Ave. Duration
- 58 min
- When
- Every day
- Estimated price
- €70–350
Flights from Zurich Airport to Stuttgart Airport
- Ave. Duration
- 45 min
- When
- Every day
- Estimated price
- €65–550
- Website
- airdolomiti.it
Flights from Milano Malpensa Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €110–340
Flights from Milan Linate Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €50–400
- Website
- eurowings.com
Flights from Milano Malpensa Airport to Stuttgart Airport
- Ave. Duration
- 1h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €75–190
Flights from Milan Linate Airport to Stuttgart Airport
- Ave. Duration
- 1h
- When
- Thursday, Friday, and Sunday
- Estimated price
- €90–270
- Website
- condor.com
Flights from Milano Malpensa Airport to Frankfurt
- Ave. Duration
- 1h 11m
- When
- Every day
- Estimated price
- €55–160
- Website
- ethiopianairlines.com
Flights from Milano Malpensa Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €75–190
Flights from Milano Malpensa Airport to Zurich Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €95–160
- Website
- easyjet.com
Flights from Milan Linate Airport to Frankfurt
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €35–140
Train from Lugano to Basel SBB
- Ave. Duration
- 2h 53m
- Frequency
- Every 3 hours
- Estimated price
- €75–120
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Varese to Malpensa Aeroporto T1
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €12–19
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Varese to Malpensa Aeroporto T1
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €12–19
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Varese to Malpensa Aeroporto T1
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €12–19
- Website
- Swiss Federal Railways (SBB CFF FFS)
Train from Zürich HB to Basel SBB
- Ave. Duration
- 1h 13m
- Frequency
- Every 20 minutes
- Estimated price
- €26–40
- Website
- Swiss Federal Railways (SBB CFF FFS)
- Phone
- +39 06 68475475
- [email protected]
- Website
- Trenitalia Eurocity
Train from Lugano to Basel SBB
- Ave. Duration
- 2h 53m
- Frequency
- 4 times a day
- Estimated price
- €55–110
- Website
- Trenitalia Eurocity
- 1st Class
- €75–110
- 2nd Class
- €55–80
Train from Lugano to Karlsruhe Hbf
- Ave. Duration
- 4h 59m
- Frequency
- Twice daily
- Estimated price
- €95–150
- Website
- Trenitalia Eurocity
- 1st Class
- €100–150
- 2nd Class
- €95–130
Train from Lugano to Zuerich Hb
- Ave. Duration
- 1h 57m
- Frequency
- Hourly
- Estimated price
- €40–90
- Website
- Trenitalia Eurocity
- 1st Class
- €60–90
- 2nd Class
- €40–60
- Phone
- +49 (0) 7531 915109
- [email protected]
- Website
- SBB GmbH
Train from Lugano to Basel SBB
- Ave. Duration
- 2h 56m
- Frequency
- Once daily
- Estimated price
- €20–25
- Schedules at
- SBB GmbH
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Basel SBB to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 41m
- Frequency
- Hourly
- Estimated price
- €35–75
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 54 min
- Frequency
- Hourly
- Estimated price
- €15–30
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 54 min
- Frequency
- Hourly
- Estimated price
- €15–30
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 8m
- Frequency
- Every 3 hours
- Estimated price
- €24–50
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Basel SBB to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 41m
- Frequency
- Hourly
- Estimated price
- €35–75
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 54 min
- Frequency
- Hourly
- Estimated price
- €15–30
- Website
- Deutsche Bahn Intercity (DB IC)
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 8m
- Frequency
- Every 3 hours
- Estimated price
- €24–50
- Website
- Deutsche Bahn Intercity (DB IC)
- Phone
- +39 02 7249 4494
- [email protected]
- Website
- Trenord
Train from Varese to Malpensa Aeroporto T1
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €4–5
- Website
- Trenord
Train from Varese to Castione
- Ave. Duration
- 1h 18m
- Frequency
- Hourly
- Estimated price
- €5–7
- Website
- Trenord
Train from Gavirate to Milano Cadorna
- Ave. Duration
- 1h 12m
- Frequency
- Hourly
- Estimated price
- €5–7
- Website
- Trenord
Train from Varese to Malpensa Aeroporto T1
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €4–5
- Website
- Trenord
Train from Varese to Malpensa Aeroporto T1
- Ave. Duration
- 41 min
- Frequency
- Hourly
- Estimated price
- €4–5
- Website
- Trenord
Train from Gavirate to Milano Cadorna
- Ave. Duration
- 1h 12m
- Frequency
- Hourly
- Estimated price
- €5–7
- Website
- Trenord
- Phone
- +49 711 400 534 44
- [email protected]
- Website
- Arverio Baden-Württemberg
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 53 min
- Frequency
- Every 30 minutes
- Estimated price
- €14–27
- Schedules at
- Arverio Baden-Württemberg
- 2nd Class Ticket
- €14–18
- 1st Class Ticket
- €18–27
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 53 min
- Frequency
- Every 30 minutes
- Estimated price
- €14–27
- Schedules at
- Arverio Baden-Württemberg
- 2nd Class Ticket
- €14–18
- 1st Class Ticket
- €18–27
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 53 min
- Frequency
- Every 30 minutes
- Estimated price
- €14–27
- Schedules at
- Arverio Baden-Württemberg
- 2nd Class Ticket
- €14–18
- 1st Class Ticket
- €18–27
- Phone
- +49 711 400 534 44
- [email protected]
- Website
- Arverio Baden-Württemberg GmbH
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- €14–20
- Schedules at
- Arverio Baden-Württemberg GmbH
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- €14–20
- Schedules at
- Arverio Baden-Württemberg GmbH
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 53 min
- Frequency
- Hourly
- Estimated price
- €14–20
- Schedules at
- Arverio Baden-Württemberg GmbH
- Phone
- +49 30 2970
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 1h 30m
- Frequency
- Once daily
- Estimated price
- €13–60
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 1h 30m
- Frequency
- Once daily
- Estimated price
- €13–60
- Website
- Deutsche Bahn Regio (DB Regional)
Train from Stuttgart Hbf to Karlsruhe Hbf
- Ave. Duration
- 1h 30m
- Frequency
- Once daily
- Estimated price
- €13–60
- Website
- Deutsche Bahn Regio (DB Regional)
- Phone
- +41 58 580 70 70
- Website
- Schweizerische Südostbahn AG
Train from Castione-Arbedo to Zürich HB
- Ave. Duration
- 2h 52m
- Frequency
- Every 4 hours
- Estimated price
- €55–85
- Schedules at
- Schweizerische Südostbahn AG
- Phone
- +43 (0) 51717
- Website
- Nightjet
Night train from Zuerich Hb to Karlsruhe Hbf
- Ave. Duration
- 3h 15m
- Frequency
- 4 times a day
- Estimated price
- €24–93
- Website
- Nightjet
- Sleeper Carriage
- €88–93
- Couchette Carriage
- €55–65
- Seating Carriage
- €24–29
- Phone
- +31 30 751 5155
- Website
- Nederlandse Spoorwegen (NS)
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 53m
- Frequency
- Twice daily
- Estimated price
- €14–29
- Website
- Nederlandse Spoorwegen (NS)
Train from Frankfurt to Karlsruhe Hauptbahnhof
- Ave. Duration
- 1h 53m
- Frequency
- Twice daily
- Estimated price
- €14–29
- Website
- Nederlandse Spoorwegen (NS)
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Como Grandate to Karlsruhe central train station
- Ave. Duration
- 9h 5m
- Frequency
- 5 times a week
- Estimated price
- €40–70
- Website
- Flixbus
Want to know more about travelling around Germany
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italian Lakes: Getting around by train
Read the travel guide
Italy Travel Guides
Read the travel guide
Heading to Europe? Read this before you buy a Eurail Pass
Read the travel guide
Booking & Getting There
Ispra to Karlsruhe bus services, operated by FlixBus, arrive at Karlsruhe central train station.
Ispra to Karlsruhe train services, operated by Swiss Federal Railways (SBB CFF FFS), arrive at Basel SBB station.
Yes, the driving distance between Ispra to Karlsruhe is 490 km. It takes approximately 5h 9m to drive from Ispra to Karlsruhe.
There are 898+ hotels available in Karlsruhe.



















































