There are 8 ways to get from Istanbul to Mesopotamía by plane, bus, car or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Recommended option
Fly to Thessaloniki, bus • 7h 14m
Cheapest option
Bus • 16h 13m
6 alternative options
Fly to Tirana, bus • 7h 8m
Fly to Pristina, drive • 6h 46m
Fly to Skopje, train, drive • 9h 34m
Bus via Kateríni • 14h 37m
Bus #2 • 16h 32m
Drive • 8h 26m
Questions & Answers
The cheapest way to get from Istanbul to Mesopotamía is to bus which costs 1.900 ₺ - 2.400 ₺ and takes 16h 13m.
The fastest way to get from Istanbul to Mesopotamía is to fly and drive which takes 6h 46m and costs 6.500 ₺ - 16.000 ₺.
The distance between Istanbul and Mesopotamía is 750 km. The road distance is 782.7 km.
The best way to get from Istanbul to Mesopotamía without a car is to bus via Kateríni which takes 14h 37m and costs 3.300 ₺ - 4.900 ₺.
It takes approximately 7h 14m to get from Istanbul to Mesopotamía, including transfers.
Yes, the driving distance between Istanbul to Mesopotamía is 783 km. It takes approximately 8h 26m to drive from Istanbul to Mesopotamía.
There are 122+ hotels available in Mesopotamía. Prices start at €29 per night.
- Distance: 750.4 km
- Duration: 7h 14m
What companies run services between Istanbul, Turkey and Mesopotamía, Greece?
You can take a bus from Istanbul to Mesopotamía via Katerini, Kateríni, Thessaloniki Macedonia KTEL Bus Station, and Kastoria in around 14h 37m.
- Website
- turkishairlines.com
Flights from Istanbul to Thessaloniki
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €140 - €490
Flights from Istanbul to Tirana
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €140 - €420
Flights from Istanbul to Pristina
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €100 - €420
Flights from Istanbul to Skopje
- Ave. Duration
- 1h 27m
- When
- Every day
- Estimated price
- €130 - €550
- Website
- airalbania.com.al
Flights from Istanbul to Tirana
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €140 - €420
- Website
- en.aegeanair.com
Flights from Istanbul to Thessaloniki
- Ave. Duration
- 1h 20m
- When
- Every day
- Estimated price
- €140 - €490
Flights from Istanbul to Thessaloniki via Athens
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- €120 - €430
- Phone
- +389 (2) 3 164 255
- mztransportad@mztransportad.com.mk
- Website
- mzt.mk
Train from Skopje to Zabeni
- Ave. Duration
- 3h 46m
- Frequency
- Once daily
- Estimated price
- €11 - €40
- Schedules at
- mzt.mk
- Website
- ktel-kastorias.gr
Bus from Thessaloniki Macedonia KTEL Bus Station to Kastoria
- Ave. Duration
- 3h
- Frequency
- 5 times a day
- Estimated price
- €20
- Schedules at
- ktel-kastorias.gr
- Website
- gjirafa.com
Bus from Tirana to Bilisht
- Ave. Duration
- 3h 20m
- Frequency
- Once daily
- Estimated price
- €8
- Schedules at
- https://travel.gjirafa.com/en
- Phone
- +30 2310241545
- crazy.holidays.tours@gmail.com
- Website
- crazyholidays.gr
Bus from Istanbul to Katerini
- Ave. Duration
- 9h
- Frequency
- Once a week
- Estimated price
- €55 - €100
- Website
- https://www.crazyholidays.gr/root.en.aspx
- Phone
- 23510 46720
- Website
- ktelpierias.gr
Bus from Kateríni to Thessaloniki Macedonia KTEL Bus Station
- Ave. Duration
- 50 min
- Frequency
- Hourly
- Estimated price
- €7
- Schedules at
- ktelpierias.gr
- Phone
- +90 212 658 18 51
- info@alparturizm.com.tr
- Website
- alparturizm.com.tr
Bus from Istanbul to Thessaloniki Macedonia KTEL Bus Station
- Ave. Duration
- 12h
- Frequency
- Once daily
- Estimated price
- €24 - €35
- Website
- https://www.alparturizm.com.tr/en/
- Phone
- 0850 222 34 55
- iletisim@metroturizm.com.tr
- Website
- metroturizm.com.tr
Bus from Istanbul Otogari to Thessaloniki
- Ave. Duration
- 11h 45m
- Frequency
- Once daily
- Estimated price
- €15 - €23
- Website
- https://www.metroturizm.com.tr/en
- Phone
- +355 67 604 2191
Bus from Thessaloníki to Kapshtice
- Ave. Duration
- 3h 25m
- Frequency
- Once daily
- Schedules at
- autobus.al
Want to know more about travelling around the world?
Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including What documents do I need to cross Niagara Falls?, Why you should take the train in the US and Travelling Croatia’s Dalmatian Coast by boat, bus, car and train - to help you get the most out of your next trip.