There are 6 ways to get from Istres to Lyon by train (TGV, Trenitalia), bus, car, train, plane, or rideshare
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train via Avignon
best- Take the train from Miramas to Avignon Centretrain C7 / ...
- Take the train from Avignon Tgv to Lyon Part Dieutrain Tgv
3h 37m€42–100Rideshare
cheapest- Take the rideshare from Istres to Lyon284.3 km
3h 18m€15–21Bus
- Take the bus from Marseille - Saint-Charles Bus Station to Lyon - Gerland Bus Stationbus BlaBlaCar Bus
6h 29m€32–56Drive 282.4 km
- Drive from Istres to Lyoncar 282.4 km
2h 51m€46–66Train, fly
- Take the train from Istres to Miramastrain
- Take the train from Miramas to Vitrolles Aéroport Marseille Ptrain
- Fly from Marseille Provence Airport (MRS) to Lyon–Saint Exupéry Airport (LYS)plane MRS - LYS
3h 36m€110–293Train
- Take the train from Miramas to Lyon Part Dieutrain K14
4h 33m€51–111
Istres to Lyon by train
Comparing Your Travel Options
The cheapest way to get from Istres to Lyon is to rideshare which costs €15 - €21 and takes 3h 18m.
The fastest way to get from Istres to Lyon is to drive which takes 2h 51m and costs €45 - €70.
No, there is no direct bus from Istres to Lyon station. However, there are services departing from Gare Istres and arriving at Lyon - Gerland Bus Station via Pôle d'Echange and Marseille - Saint-Charles Bus Station. The journey, including transfers, takes approximately 6h 29m.
No, there is no direct train from Istres to Lyon. However, there are services departing from Istres and arriving at Lyon Part Dieu via Miramas, Avignon Centre and Avignon Tgv. The journey, including transfers, takes approximately 3h 37m.
The distance between Istres and Lyon is 310 km. The road distance is 282.4 km.
The best way to get from Istres to Lyon without a car is to train via Avignon which takes 3h 37m and costs €40 - €100.
It takes approximately 3h 37m to get from Istres to Lyon, including transfers.
Istres to Lyon bus services, operated by BlaBlaCar Bus, depart from Marseille - Saint-Charles Bus Station.
Istres to Lyon train services, operated by Zou! Lignes Express Régionales, depart from Miramas station.
The best way to get from Istres to Lyon is to train via Avignon which takes 3h 37m and costs €40 - €100. Alternatively, you can bus, which costs €30 - €60 and takes 6h 29m.
What companies run services between Istres, France and Lyon, France?
You can take a train from Istres to Lyon Part Dieu via Miramas, Avignon Centre, and Avignon Tgv in around 3h 37m. Alternatively, BlaBlaCar Bus operates a bus from Marseille - Saint-Charles Bus Station to Lyon - Gerland Bus Station hourly. Tickets cost €24–40 and the journey takes 4h 30m. FlixBus also services this route twice daily.
- Website
- airfrance.com
Flights from Marseille Provence Airport to Lyon–Saint Exupéry Airport
- Ave. Duration
- 55 min
- When
- Monday to Thursday
- Estimated price
- €40–300
- Phone
- +33 4 13 94 30 50
- Website
- Zou! Lignes Express Régionales
Train from Miramas to Avignon Centre
- Ave. Duration
- 1h 7m
- Frequency
- Hourly
- Estimated price
- €17–24
- Website
- Zou! Lignes Express Régionales
Train from Istres to Miramas
- Ave. Duration
- 9 min
- Frequency
- Hourly
- Estimated price
- €2–4
- Website
- Zou! Lignes Express Régionales
Train from Miramas to Vitrolles Aéroport Marseille P
- Ave. Duration
- 22 min
- Frequency
- Every 30 minutes
- Estimated price
- €8–11
- Website
- Zou! Lignes Express Régionales
Train from Miramas to Lyon Part Dieu
- Ave. Duration
- 3h 17m
- Frequency
- 3 times a day
- Estimated price
- €75–110
- Website
- Zou! Lignes Express Régionales
Rome2Rio's guide to Société Nationale des Chemins de fer Français (SNCF)
Contact DetailsContact Details
- Phone
- +33 1 84 94 36 35
- Website
- Oui.SNCF
Train from Miramas to Avignon Centre
- Ave. Duration
- 1h 8m
- Frequency
- Hourly
- Estimated price
- €12–21
- Website
- Oui.SNCF
Train from Avignon Tgv to Lyon Part Dieu
- Ave. Duration
- 1h 6m
- Frequency
- Twice daily
- Estimated price
- €40–70
- Website
- Oui.SNCF
Train from Istres to Miramas
- Ave. Duration
- 9 min
- Frequency
- Hourly
- Estimated price
- €1–4
- Website
- Oui.SNCF
Train from Miramas to Vitrolles Aéroport Marseille P
- Ave. Duration
- 22 min
- Frequency
- Every 30 minutes
- Estimated price
- €5–9
- Website
- Oui.SNCF
Train from Miramas to Lyon Part Dieu
- Ave. Duration
- 3h 17m
- Frequency
- 3 times a day
- Estimated price
- €50–90
- Website
- Oui.SNCF
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Miramas to Avignon Centre
- Ave. Duration
- 39 min
- Frequency
- Twice daily
- Estimated price
- €13–21
- Website
- TGV inOui
Train from Avignon Tgv to Lyon Part Dieu
- Ave. Duration
- 1h 4m
- Frequency
- Hourly
- Estimated price
- €45–70
- Website
- TGV inOui
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Avignon Tgv to Lyon Part Dieu
- Ave. Duration
- 1h 9m
- Frequency
- Once daily
- Estimated price
- €27–40
- Website
- Trenitalia
- Phone
- +32 70 79 79 79
- Website
- Belgian Railways
Train from Avignon Tgv to Lyon Part Dieu
- Ave. Duration
- 1h 5m
- Frequency
- Twice a week
- Estimated price
- €40–65
- Website
- Belgian Railways
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Marseille - Saint-Charles Bus Station to Lyon - Gerland Bus Station
- Ave. Duration
- 4h 30m
- Frequency
- Hourly
- Estimated price
- €24–40
- Website
- BlaBlaCar Bus
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Marseille - Saint-Charles Bus Station to Lyon - Gerland Bus Station
- Ave. Duration
- 3h 50m
- Frequency
- Twice daily
- Estimated price
- €28–45
- Website
- Flixbus
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar
Rideshare from Istres to Lyon
- Ave. Duration
- 3h 18m
- Frequency
- Once daily
- Estimated price
- €15–21
- Schedules at
- BlaBlaCar
Want to know more about travelling around France
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Booking & Getting There
Istres to Lyon bus services, operated by BlaBlaCar Bus, arrive at Lyon - Gerland Bus Station.
Istres to Lyon train services, operated by Zou! Lignes Express Régionales, arrive at Avignon Centre station.
Yes, the driving distance between Istres to Lyon is 282 km. It takes approximately 2h 51m to drive from Istres to Lyon.
Book your Istres to Lyon train tickets online with Omio.
There are 3926+ hotels available in Lyon.
Check out Blablacar's carpooling service for rideshare options between Istres and Lyon. A great option if you don't have a driver's licence or want to avoid public transport.



























