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How to get fromIthaca, NY to Chicagoby bus, plane, train, bus (Flixbus, Greyhound), or car

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There are 9 ways to get from Ithaca, NY to Chicago by bus, plane, train, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Rochester, fly to Chicago Midway International Airport

    best
    1. Take the bus from Ithaca to Rochester, Nybus bus
    2. Fly from Rochester (ROC) to Chicago Midway International Airport (MDW)plane plane ROC - MDW
    5h 25m
    $117–512

  2. Bus to Syracuse Hancock International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Ithaca to Syracuse Bus Stationbus bus
    2. Fly from Syracuse Hancock International Airport (SYR) to Chicago O'Hare International Airport (ORD)plane plane SYR - ORD
    6h 34m
    $94–496

  3. Bus, train

    1. Take the bus from Ithaca to Syracuse Bus Stationbus bus FlixBus 2691
    2. Take the train from Syracuse Regional Transportation Center to Chicago Union Stationtrain train Lake Shore Limited
    15h 25m
    $179–414

  4. Bus

    1. Take the bus from Ithaca to Buffalobus bus
    2. Take the bus from Buffalo to Cleveland Bus Stationbus bus
    3. Take the bus from Cleveland Bus Station to Chicago Bus Stationbus bus
    16h 33m
    $96–187

  5. Drive  656.8 mi

    1. Drive from Ithaca, NY to Chicagocar car 656.8 mi
    11h 41m
    $120–174

  6. Bus to Rochester, fly to Chicago O'Hare International Airport

    1. Take the bus from Ithaca to Rochester, Nybus bus
    2. Fly from Rochester (ROC) to Chicago O'Hare International Airport (ORD)plane plane ROC - ORD
    5h 55m
    $107–452

  7. Bus to Buffalo Niagara International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Ithaca to Buffalobus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago Midway International Airport (MDW)plane plane BUF - MDW
    6h 55m
    $184–350

  8. Bus to Buffalo Niagara International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Ithaca to Buffalobus bus
    2. Fly from Buffalo Niagara International Airport (BUF) to Chicago O'Hare International Airport (ORD)plane plane BUF - ORD
    7h 12m
    $194–340

  9. Bus to Wilkes-Barre/Scranton International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Ithaca to Scrantonbus bus
    2. Fly from Wilkes-Barre/Scranton International Airport (AVP) to Chicago O'Hare International Airport (ORD)plane plane AVP - ORD
    7h
    $127–494

Ithaca, NY to Chicago by foot, bus, and train

Calendar3Weekly Services
Duration15h 25mAverage Duration
Ticket$179Cheapest Price
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Questions & Answers

Map of how to get from Ithaca, NY to Chicago.ExpandLaunch map view
  • Distance: 629 mi
  • Duration: 5h 25m

What companies run services between Ithaca, NY, USA and Chicago, IL, USA?

You can take a vehicle from Ithaca, NY to Chicago Bus Station via Ithaca, Buffalo, and Cleveland Bus Station in around 16h 33m.

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Train operators
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