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How to get fromIthaca to Knoxvilleby plane, bus (Flixbus), car, bus, or train

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There are 10 ways to get from Ithaca to Knoxville by plane, bus (Flixbus), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Ithaca Tompkins Regional Airport

    best
    1. Fly from Ithaca Tompkins Regional Airport (ITH) to Mcghee Tyson Airport (TYS)plane plane ITH - TYS
    5h 52m
    $190–751

  2. Drive 711.2 mi

    cheapest
    1. Drive from Ithaca to Knoxvillecar car 711.2 mi
    13h 4m
    $130–188

  3. Bus via Farragut

    1. Take the bus from Ithaca to New York Midtownbus bus FlixBus 2683 / ...
    2. Take the bus from New York to Knoxvillebus bus Nyc
    17h 53m
    $221–314

  4. Bus to Rochester, fly

    1. Take the bus from Ithaca to Rochester, Nybus bus
    2. Fly from Rochester (ROC) to Mcghee Tyson Airport (TYS)plane plane ROC - TYS
    7h 6m
    $275–1,097

  5. Bus to Greater Binghamton Airport, fly

    1. Take the bus from Ithaca to Binghamtonbus bus
    2. Fly from Greater Binghamton Airport (BGM) to Mcghee Tyson Airport (TYS)plane plane BGM - TYS
    7h 51m
    $248–878

  6. Bus to Elmira/Corning Regional Airport, fly

    1. Take the bus from Ithaca - Tioga Street and Seneca Street to Transit Center - PO Sidebus bus
    2. Fly from Elmira/Corning Regional Airport (ELM) to Mcghee Tyson Airport (TYS)plane plane ELM - TYS
    7h 53m
    $201–828

  7. Bus to Syracuse Hancock International Airport, fly

    1. Take the bus from Ithaca to Syracuse Bus Stationbus bus
    2. Fly from Syracuse Hancock International Airport (SYR) to Mcghee Tyson Airport (TYS)plane plane SYR - TYS
    7h 51m
    $248–1,063

  8. Bus

    1. Take the bus from Ithaca, NY to New York, NYbus bus
    2. Take the bus from Willow Ave At 15Th St to Port Authority Bus Terminalbus bus 126 / ...
    3. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    18h 8m
    $216–348

  9. Bus via New York

    1. Take the bus from Ithaca to Port Authority Bus Terminalbus bus 231
    2. Take the bus from New York to Knoxvillebus bus Nyc
    18h 18m
    $220–392

  10. Bus, train

    1. Take the bus from Ithaca to Syracuse Bus Stationbus bus
    2. Take the train from Syracuse Regional Transportation Center to Albany-Rensselaer Amtrak Stationtrain train
    3. Take the train from Albany-Rensselaer Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    21h 54m
    $233–464

Ithaca Tompkins Regional Airport (ITH) to Mcghee Tyson Airport (TYS) flights

Calendar15Weekly Planes
Duration4h 16mAverage Duration
Ticket$134Cheapest Price
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Questions & Answers

Map of how to get from Ithaca to Knoxville.ExpandLaunch map view
  • Distance: 633.3 mi
  • Duration: 5h 52m

What companies run services between Ithaca, NY, USA and Knoxville, TN, USA?

United Airlines flies from Ithaca Tompkins Regional Airport (ITH) to Mcghee Tyson Airport (TYS) twice daily. Alternatively, you can take a bus from Ithaca to Knoxville via New York Midtown, 34 St-Herald Sq, East Broadway, New York, and Knoxville in around 17h 53m.

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