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How to get fromJacksonville to Buffaloby plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

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There are 8 ways to get from Jacksonville to Buffalo by plane, bus (Greyhound), bus, train, car, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Albert J. Ellis Airport

    best
    1. Fly from Albert J. Ellis Airport (OAJ) to Buffalo Niagara International Airport (BUF)plane plane OAJ - BUF
    5h 13m
    $144–667

  2. Drive 668.7 mi

    cheapest
    1. Drive from Jacksonville to Buffalocar car 668.7 mi
    13h 51m
    $122–177

  3. Bus via Chesapeake

    1. Take the bus from Jacksonville Bus Stop to Norfolkbus bus
    2. Take the bus from Norfolk, VA - Best Square to Times Square – 37th St.bus bus
    3. Take the bus from New York to Buffalobus bus
    22h 16m
    $145–406

  4. Bus, train via New York

    1. Take the bus from Jacksonville Bus Stop to Wilson Bus Stopbus bus
    2. Take the train from Wilson to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train
    22h 57m
    $310–647

  5. Bus to Wilmington International Airport, fly

    1. Take the bus from Jacksonville Bus Stop to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Buffalo Niagara International Airport (BUF)plane plane ILM - BUF
    7h 6m
    $123–611

  6. Bus to Coastal Carolina Regional Airport, fly

    1. Take the bus from Jacksonville Bus Stop to New Bernbus bus
    2. Fly from Coastal Carolina Regional Airport (EWN) to Buffalo Niagara International Airport (BUF)plane plane EWN - BUF
    7h 11m
    $140–655

  7. Bus

    1. Take the bus from Jacksonville Bus Stop to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Newark Penn Stationbus bus
    3. Take the bus from Newark Penn Station to Buffalobus bus
    23h 3m
    $157–310

  8. Bus, train

    1. Take the bus from Jacksonville Bus Stop to Raleigh Bus Stationbus bus
    2. Take the train from Raleigh Union Station to Pittsburgh Amtrak Stationtrain train
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    28h 50m
    $254–632

Jacksonville to Buffalo by bus and train

Calendar14Weekly Services
Duration22h 57mAverage Duration
Ticket$310Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to Buffalo.ExpandLaunch map view
  • Distance: 590.7 mi
  • Duration: 5h 13m

What companies run services between Jacksonville, NC, USA and Buffalo, NY, USA?

American Airlines and Delta fly from Albert J. Ellis Airport (OAJ) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a bus from Jacksonville Bus Stop to Buffalo via Norfolk, VA - Best Square, Times Square – 37th St., and New York in around 22h 16m.

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