Rome2Rio

How to get fromJacksonville to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Amtrak, Greyhound)

Find Transport to Louisville

See all options

There are 9 ways to get from Jacksonville to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), bus, train, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Albert J. Ellis Airport to Louisville International Airport

    best
    1. Fly from Albert J. Ellis Airport (OAJ) to Louisville International Airport (SDF)plane plane OAJ - SDF
    5h 34m
    $123–591

  2. Bus to Wilmington International Airport, fly to Louisville International Airport

    cheapest
    1. Take the bus from Jacksonville Bus Stop to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Louisville International Airport (SDF)plane plane ILM - SDF
    7h 2m
    $107–585

  3. Bus via Atlanta

    1. Take the bus from Jacksonville Bus Stop to Myrtle Beach Bus Stationbus bus
    2. Take the bus from Myrtle Beach Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    4. Take the bus from Nashville to Louisville, KYbus bus
    23h 15m
    $134–265

  4. Bus, train

    1. Take the bus from Jacksonville Bus Stop to Wilson Bus Stopbus bus
    2. Take the train from Wilson to Alexandriatrain train
    3. Take the train from Alexandria to Indianapolistrain train
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    31h 8m
    $321–702

  5. Drive 623.9 mi

    1. Drive from Jacksonville to Louisvillecar car 623.9 mi
    12h 7m
    $114–165

  6. Fly Albert J. Ellis Airport to Blue Grass Airport, drive

    1. Fly from Albert J. Ellis Airport (OAJ) to Blue Grass Airport (LEX)plane plane OAJ - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 17m
    $165–807

  7. Bus to Coastal Carolina Regional Airport, fly to Louisville International Airport

    1. Take the bus from Jacksonville Bus Stop to New Bernbus bus
    2. Fly from Coastal Carolina Regional Airport (EWN) to Louisville International Airport (SDF)plane plane EWN - SDF
    6h 58m
    $114–579

  8. Bus to Greenville, fly to Louisville International Airport

    1. Take the bus from Jacksonville Bus Stop to Greenville GK Butterfield Trans Ctrbus bus
    2. Fly from Greenville (PGV) to Louisville International Airport (SDF)plane plane PGV - SDF
    8h 44m
    $117–590

  9. Bus

    1. Take the bus from Jacksonville Amtrak Bus Stop to Wilsonbus bus
    2. Take the bus from Wilson Bus Stop to Winston Salem(Trans Center)bus bus
    3. Take the bus from Winston Salem(Trans Center) to Columbus - Mound Stbus bus
    4. Take the bus from Columbus - Downtown - Mound St to Louisville, KY Bus Stationbus bus
    24h 55m
    $139–279

Jacksonville to Louisville by bus

Calendar7Weekly Buses
Duration23h 15mAverage Duration
Ticket$134Cheapest Price
See schedules

Questions & Answers

Map of how to get from Jacksonville to Louisville.ExpandLaunch map view
  • Distance: 527.3 mi
  • Duration: 5h 34m

What companies run services between Jacksonville, NC, USA and Louisville, KY, USA?

American Airlines and Delta fly from Albert J. Ellis Airport (OAJ) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a bus from Jacksonville Bus Stop to Louisville, KY via Myrtle Beach Bus Station, Atlanta Bus Station, and Nashville in around 23h 15m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers