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How to get fromJacksonville to St. Louisby plane, bus (Greyhound, Flixbus), bus, train, or car

Find Transport to St. Louis

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There are 7 ways to get from Jacksonville to St. Louis by plane, bus (Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Albert J. Ellis Airport

    best
    1. Fly from Albert J. Ellis Airport (OAJ) to Lambert–St. Louis International Airport (STL)plane plane OAJ - STL
    5h 23m
    $145–641

  2. Bus to Coastal Carolina Regional Airport, fly

    cheapest
    1. Take the bus from Jacksonville Bus Stop to New Bernbus bus
    2. Fly from Coastal Carolina Regional Airport (EWN) to Lambert–St. Louis International Airport (STL)plane plane EWN - STL
    6h 52m
    $131–629

  3. Bus

    1. Take the bus from Jacksonville Bus Stop to Raleigh Bus Stationbus bus
    2. Take the bus from Raleigh Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus
    25h 36m
    $167–330

  4. Bus, train

    1. Take the bus from Jacksonville Bus Stop to Raleigh Bus Stationbus bus
    2. Take the train from Raleigh Union Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Louistrain train
    35h 51m
    $454–992

  5. Drive 882.4 mi

    1. Drive from Jacksonville to St. Louiscar car 882.4 mi
    16h 21m
    $161–233

  6. Bus to Wilmington International Airport, fly

    1. Take the bus from Jacksonville Bus Stop to Wilmington Cape Fear Public Transitbus bus
    2. Fly from Wilmington International Airport (ILM) to Lambert–St. Louis International Airport (STL)plane plane ILM - STL
    7h 14m
    $134–585

  7. Bus, train via Atlanta

    1. Take the bus from Jacksonville Amtrak Bus Stop to Wilsonbus bus
    2. Take the train from Wilson to Durham Amtrak Stationtrain train
    3. Take the bus from Durham to Atlanta Downtownbus bus
    4. Take the bus from Atlanta Bus Station to Carbondale Intermodal Stationbus bus
    5. Take the bus from Carbondale Intermodal Station to St Louis Bus Stationbus bus
    28h 7m
    $232–406

Jacksonville to St. Louis by bus

Calendar14Weekly Buses
Duration25h 36mAverage Duration
Ticket$167Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to St. Louis.ExpandLaunch map view
  • Distance: 782.7 mi
  • Duration: 5h 23m

What companies run services between Jacksonville, NC, USA and St. Louis, MO, USA?

Delta and American Airlines fly from Albert J. Ellis Airport (OAJ) to Lambert–St. Louis International Airport (STL) every 4 hours. Alternatively, you can take a bus from Jacksonville Bus Stop to St Louis Bus Station via Raleigh Bus Station and Atlanta Bus Station in around 25h 36m.

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