Rome2Rio

How to get fromJacksonville (Station) to Florida Keysby bus, shuttle, train, car, plane, or bus (Flixbus, Greyhound)

Find Transport to Florida Keys

See all options

There are 9 ways to get from Jacksonville (Station) to Florida Keys by bus, shuttle, train, car, plane, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from Jacksonville to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Fort Lauderdale International Airportbus bus
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    15h 13m
    $226–292

  2. Drive  492.1 mi

    cheapest
    1. Drive from Jacksonville (Station) to Florida Keyscar car 492.1 mi
    8h 52m
    $87–126

  3. Train, bus

    1. Take the train from Jacksonville to Fort Lauderdale Amtrak Stationtrain train
    2. Take the train from Fort Lauderdale Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    15h 49m
    $244–375

  4. Line 4 bus to Jacksonville, fly to Key West International Airport, bus

    1. Take the bus from Amtrak Station to JRTC Bay Hbus bus
    2. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    3. Take the bus from Whitehead & Eaton to Sugarloaf Key - Lower - Opposite Sugarloaf Lodgebus bus
    9h 27m
    $120–350

  5. Bus

    1. Take the bus from Jacksonville to Miami Airport Stationbus bus FlixBus 2431 / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    17h
    $92–162

  6. Drive to Orlando Sanford, fly to Key West International Airport

    1. Drive from Jacksonville (Station) to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    6h 39m
    $135–367

  7. Fly Jacksonville to Miami International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Miami International Airport (MIA)plane plane JAX - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 1m
    $195–470

  8. Fly Jacksonville to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane JAX - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 28m
    $295–580

  9. Train to Orlando, fly to Key West International Airport

    1. Take the train from Jacksonville to Winter Park Amtrak Stationtrain train
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    9h 38m
    $225–920

Jacksonville (Station) to Florida Keys by foot, bus, and shuttle

Calendar21Weekly Services
Duration15h 13mAverage Duration
Ticket$226Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Jacksonville (Station) to Florida Keys.ExpandLaunch map view
  • Distance: 525.3 mi
  • Duration: 15h 13m

What companies run services between Jacksonville (Station), FL, USA and Florida Keys, FL, USA?

You can take a vehicle from Jacksonville (Station) to Florida Keys via Amtrak Station, JRTC Bay H, Jacksonville, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 17h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound