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How to get fromJacksonville (Station) to Florida Keysby train, bus, bus (Flixbus, Greyhound), car, plane, or shuttle

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There are 9 ways to get from Jacksonville (Station) to Florida Keys by train, bus, bus (Flixbus, Greyhound), car, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Jacksonville to Hollywood Amtrak Stationtrain train Silver Meteor / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    15h 49m
    $155–310

  2. Bus

    cheapest
    1. Take the bus from Jacksonville to Miami Airport Stationbus bus FlixBus 2431
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    16h 37m
    $84–167

  3. Drive 492.1 mi

    1. Drive from Jacksonville (Station) to Florida Keyscar car 492.1 mi
    8h 52m
    $90–130

  4. Fly Jacksonville to Key West International Airport

    1. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    9h 36m
    $440–900

  5. Bus, shuttle

    1. Take the bus from Jacksonville to Orlandobus bus
    2. Take the bus from Orlando RedCoach Station to Miami Airportbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    17h 10m
    $241–349

  6. Drive to Orlando Sanford, fly to Key West International Airport

    1. Drive from Jacksonville (Station) to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    6h 36m
    $135–378

  7. Fly Jacksonville to Miami International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Miami International Airport (MIA)plane plane JAX - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    9h 51m
    $210–530

  8. Fly Jacksonville to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane JAX - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    10h 17m
    $295–960

  9. Train to Orlando, fly to Key West International Airport

    1. Take the train from Jacksonville to Winter Park Amtrak Stationtrain train
    2. Fly from Orlando (MCO) to Key West International Airport (EYW)plane plane MCO - EYW
    9h 30m
    $193–842

Jacksonville (Station) to Florida Keys by train, bus, and foot

Calendar14Weekly Services
Duration15h 49mAverage Duration
Ticket$155Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville (Station) to Florida Keys.ExpandLaunch map view
  • Distance: 555.6 mi
  • Duration: 15h 49m

What companies run services between Jacksonville (Station), FL, USA and Florida Keys, FL, USA?

You can take a bus from Amtrak Station to Florida Keys via JRTC Bay H, Jacksonville, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 16h 37m. Alternatively, American Airlines and Delta fly from Jacksonville (JAX) to Key West International Airport (EYW) every 4 hours.

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