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How to get fromJacksonville (Station) to Florida Keysby plane, bus, shuttle, train, car, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Jacksonville (Station) to Florida Keys by plane, bus, shuttle, train, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Jacksonville to Key West International Airport

    best
    1. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    6h 36m
    $154–387

  2. Drive  492.1 mi

    cheapest
    1. Drive from Jacksonville (Station) to Florida Keyscar car 492.1 mi
    8h 52m
    $85–122

  3. Bus, shuttle

    1. Take the bus from Jacksonville to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Fort Lauderdale International Airportbus bus
    3. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Summerland Key - Mote Marine Labshuttle bus
    15h 14m
    $226–292

  4. Train, bus

    1. Take the train from Jacksonville to Fort Lauderdale Amtrak Stationtrain train
    2. Take the train from Fort Lauderdale Station to Miami Airport Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    15h 49m
    $242–374

  5. Fly Jacksonville to Miami International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Miami International Airport (MIA)plane plane JAX - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 10m
    $229–477

  6. Fly Jacksonville to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane JAX - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 37m
    $329–437

  7. Drive to Orlando Sanford, fly to Key West International Airport

    1. Drive from Jacksonville (Station) to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    6h 39m
    $134–376

  8. Bus

    1. Take the bus from Jacksonville to Miami Airport Stationbus bus FlixBus 2431 / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    17h 1m
    $91–152

Jacksonville (Station) to Florida Keys by foot, bus, and shuttle

Calendar21Weekly Services
Duration15h 14mAverage Duration
Ticket$226Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Jacksonville (Station) to Florida Keys.ExpandLaunch map view
  • Distance: 444.7 mi
  • Duration: 6h 36m

What companies run services between Jacksonville (Station), FL, USA and Florida Keys, FL, USA?

American Airlines and Delta fly from Jacksonville (JAX) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Jacksonville (Station) to Florida Keys via Amtrak Station, JRTC Bay H, Jacksonville, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 17h 1m.

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