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How to get fromJacksonville (Station) to Knoxvilleby bus, plane, train, bus (Flixbus), or car

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There are 8 ways to get from Jacksonville (Station) to Knoxville by bus, plane, train, bus (Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 4 bus to Jacksonville, fly to Mcghee Tyson Airport

    best
    1. Take the bus from Amtrak Station to JRTC Bay Hbus bus
    2. Fly from Jacksonville (JAX) to Mcghee Tyson Airport (TYS)plane plane JAX - TYS
    4h 35m
    $168–726

  2. Drive 503 mi

    cheapest
    1. Drive from Jacksonville (Station) to Knoxvillecar car 503 mi
    9h 30m
    $92–133

  3. Train, bus via Farragut

    1. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train Silver Meteor
    2. Take the bus from New York to Knoxvillebus bus Nyc
    32h 12m
    $494–893

  4. Bus

    1. Take the bus from Jacksonville to New York City Chinatownbus bus FlixBus N2472
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    37h 7m
    $261–388

  5. Drive to Orlando Sanford, fly to Mcghee Tyson Airport

    1. Drive from Jacksonville (Station) to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Mcghee Tyson Airport (TYS)plane plane SFB - TYS
    4h 22m
    $188–754

  6. Fly Jacksonville to Nashville, drive

    1. Fly from Jacksonville (JAX) to Nashville (BNA)plane plane JAX - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    7h 25m
    $108–486

  7. Train to Orlando, fly to Mcghee Tyson Airport

    1. Take the train from Jacksonville to Winter Park Amtrak Stationtrain train
    2. Fly from Orlando (MCO) to Mcghee Tyson Airport (TYS)plane plane MCO - TYS
    7h 21m
    $204–769

  8. Train, bus

    1. Take the train from Jacksonville to Ny Moynihan Train Hall At Penn Stationtrain train Silver Meteor
    2. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    32h 16m
    $449–803

Jacksonville (JAX) to Mcghee Tyson Airport (TYS) flights

Calendar5Weekly Planes
Duration2h 41mAverage Duration
Ticket$109Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville (Station) to Knoxville.ExpandLaunch map view
  • Distance: 427.6 mi
  • Duration: 4h 35m

What companies run services between Jacksonville (Station), FL, USA and Knoxville, TN, USA?

You can take a bus from Amtrak Station to Knoxville Station Hall of Fame via JRTC Bay H, Jacksonville, New York, NY, Knoxville, TN, Walmart, and Charlie Haun WB Aft Washington PK in around 37h 7m.

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