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How to get fromJacksonville to Big Pine Keyby plane, bus, shuttle, train, car, or bus (Flixbus, Greyhound)

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There are 8 ways to get from Jacksonville to Big Pine Key by plane, bus, shuttle, train, car, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Jacksonville to Key West International Airport, bus

    best
    1. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    2. Take the bus from Key West Airport to Big Pine Keybus bus
    6h 45m
    $51–281

  2. Bus, shuttle

    1. Take the bus from Jacksonville to Miami Golden Gladesbus bus FlixBus 2431
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus To the Keys
    13h 49m
    $211–280

  3. Train, bus

    1. Take the train from Jacksonville to Hollywood Amtrak Stationtrain train Silver Meteor / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    15h 42m
    $124–289

  4. Drive  474 mi

    1. Drive from Jacksonville to Big Pine Keycar car 474 mi
    8h 25m
    $87–125

  5. Fly Jacksonville to Miami International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Miami International Airport (MIA)plane plane JAX - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 16m
    $202–513

  6. Fly Jacksonville to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane JAX - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 40m
    $292–683

  7. Drive to Orlando Sanford, fly to Key West International Airport, bus

    1. Drive from Jacksonville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    3. Take the bus from Key West Airport to Big Pine Keybus bus
    5h 13m
    $62–291

  8. Bus

    1. Take the bus from Jacksonville to Miami Airport Stationbus bus FlixBus 2431 / ...
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus Greyhound US0720s
    13h 55m
    $80–159

Jacksonville to Big Pine Key by bus, train, tram, and shuttle

Calendar11Weekly Services
Duration13h 49mAverage Duration
Ticket$211Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to Big Pine Key.ExpandLaunch map view
  • Distance: 454.4 mi
  • Duration: 6h 45m

What companies run services between Jacksonville, FL, USA and Big Pine Key, FL, USA?

You can take a bus from Jacksonville to Big Pine Key via Miami Airport Station in around 13h 55m.

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