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How to get fromJacksonville to Des Moinesby plane, bus (Flixbus, Greyhound), train, bus, or car

Find Transport to Des Moines

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There are 7 ways to get from Jacksonville to Des Moines by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Jacksonville

    best
    1. Fly from Jacksonville (JAX) to Des Moines (DSM)plane plane JAX - DSM
    6h 34m
    $169–774

  2. Bus

    1. Take the bus from Jacksonville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Des Moinesbus bus
    30h 25m
    $193–382

  3. Train, bus

    1. Take the train from Jacksonville to Chicago Union Stationtrain train Floridian
    2. Take the bus from Chicago Bus Station to Des Moinesbus bus Greyhound US0123S / ...
    44h 15m
    $457–1,043

  4. Drive  1,191.5 mi

    1. Drive from Jacksonville to Des Moinescar car 1,191.5 mi
    21h 48m
    $218–315

  5. Bus to Brunswick Golden Isles Airport, fly

    1. Take the bus from Jacksonville to Brunswickbus bus
    2. Fly from Brunswick Golden Isles Airport (BQK) to Des Moines (DSM)plane plane BQK - DSM
    7h
    $182–755

  6. Bus to Gainesville Regional Airport, fly

    1. Take the bus from Jacksonville to Gainesvillebus bus
    2. Fly from Gainesville Regional Airport (GNV) to Des Moines (DSM)plane plane GNV - DSM
    8h 35m
    $179–788

  7. Drive to Orlando Sanford, fly

    1. Drive from Jacksonville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Des Moines (DSM)plane plane SFB - DSM
    5h 25m
    $200–804

Jacksonville to Des Moines by bus

Calendar7Weekly Buses
Duration30h 25mAverage Duration
Ticket$193Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to Des Moines.ExpandLaunch map view
  • Distance: 1,035.2 mi
  • Duration: 6h 34m

What companies run services between Jacksonville, FL, USA and Des Moines, IA, USA?

Delta, Southwest Airlines, and two other airlines fly from Jacksonville (JAX) to Des Moines (DSM) hourly. Alternatively, you can take a bus from Jacksonville to Des Moines via Atlanta Bus Station and Indianapolis Union Station in around 30h 25m.

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