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How to get fromJacksonville to Florida Keysby car, plane, or bus

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There are 4 ways to get from Jacksonville to Florida Keys by car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive 503.1 mi

    best
    1. Drive from Jacksonville to Key Westcar car 503.1 mi
    9h 8m
    $92–133

  2. Drive to Orlando Sanford, fly

    cheapest
    1. Drive from Jacksonville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    3h 39m
    $58–283

  3. Fly from Jacksonville

    1. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    5h 40m
    $362–803

  4. Bus to Gainesville Regional Airport, fly

    1. Take the bus from Jacksonville to Gainesvillebus bus
    2. Fly from Gainesville Regional Airport (GNV) to Key West International Airport (EYW)plane plane GNV - EYW
    7h 23m
    $58–289

Jacksonville (JAX) to Key West International Airport (EYW) flights

Calendar51Weekly Planes
Duration5h 6mAverage Duration
Ticket$55Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to Florida Keys.ExpandLaunch map view
  • Distance: 503.1 mi
  • Duration: 9h 8m

What companies run services between Jacksonville, FL, USA and Florida Keys, Monroe County, FL, USA?

American Airlines and Delta fly from Jacksonville (JAX) to Key West International Airport (EYW) every 4 hours.

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Bus operators

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