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How to get fromJacksonville to Key West, FLby plane, bus, shuttle, train, car, bus (Flixbus, Greyhound), or ferry

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There are 10 ways to get from Jacksonville to Key West, FL by plane, bus, shuttle, train, car, bus (Flixbus, Greyhound), or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Jacksonville to Key West International Airport

    best
    1. Fly from Jacksonville (JAX) to Key West International Airport (EYW)plane plane JAX - EYW
    6h 36m
    $117–343

  2. Bus, train

    cheapest
    1. Take the bus from Jacksonville to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to West Palm Beach Bus Stationbus bus
    3. Take the train from West Palm Beach Station to Miami Airport Stationtrain train
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to Whitehead & Eatonbus bus Lks
    16h 21m
    $81–133

  3. Bus, shuttle

    1. Take the bus from Jacksonville to Orlando Bus Stationbus bus
    2. Take the bus from Orlando - RedCoach Station, FL to Miami Airportbus bus
    3. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    14h 28m
    $250–315

  4. Train, bus, shuttle

    1. Take the train from Jacksonville to Hollywood Amtrak Stationtrain train
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take a shuttle bus from Big Pine Key, FL to Key West, FLshuttle bus
    15h 59m
    $340–507

  5. Drive  504.6 mi

    1. Drive from Jacksonville to Key West, FLcar car 504.6 mi
    9h 11m
    $87–125

  6. Drive to Orlando Sanford, fly to Key West International Airport

    1. Drive from Jacksonville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to Key West International Airport (EYW)plane plane SFB - EYW
    4h 54m
    $131–371

  7. Fly Jacksonville to Miami International Airport, shuttle

    1. Fly from Jacksonville (JAX) to Miami International Airport (MIA)plane plane JAX - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Key West, FLshuttle bus
    8h 17m
    $212–453

  8. Bus to Gainesville Regional Airport, fly to Key West International Airport

    1. Take the bus from Jacksonville to Gainesvillebus bus
    2. Fly from Gainesville Regional Airport (GNV) to Key West International Airport (EYW)plane plane GNV - EYW
    8h 57m
    $128–378

  9. Bus

    1. Take the bus from Jacksonville to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Big Pine Keybus bus
    3. Take the bus from Big Pine Key - CVS / MM30 to Whitehead & Eatonbus bus Lks
    16h 19m
    $92–150

  10. Bus, ferry

    1. Take the bus from Jacksonville to Orlando Bus Stationbus bus
    2. Take the bus from Orlando Bus Station to Fort Myers Bus Stopbus bus
    3. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    16h 31m
    $191–227

Jacksonville to Key West, FL by bus and shuttle

Calendar21Weekly Services
Duration14h 28mAverage Duration
Ticket$250Cheapest Price
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Comparing Your Travel Options

Map of how to get from Jacksonville to Key West, FL.ExpandLaunch map view
  • Distance: 430.4 mi
  • Duration: 6h 36m

What companies run services between Jacksonville, FL, USA and Key West, FL, USA?

American Airlines and Delta fly from Jacksonville (JAX) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a bus from Jacksonville to Whitehead & Eaton via Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 16h 19m.

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Want to know more about travelling around United States

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