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How to get fromJacksonville to La Crosseby plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus

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There are 7 ways to get from Jacksonville to La Crosse by plane, bus (Flixbus, Greyhound), train (Amtrak), car, train, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Jacksonville to La Crosse

    best
    1. Fly from Jacksonville (JAX) to La Crosse (LSE)plane plane JAX - LSE
    7h 26m
    $131–576

  2. Bus

    1. Take the bus from Jacksonville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to La Crossebus bus
    31h
    $237–427

  3. Train (Amtrak)

    1. Take the train from Jacksonville to Chicago Union Stationtrain train Floridian
    2. Take the train from Chicago Union Station to La Crosse Amtrak Stationtrain train Empire Builder / ...
    42h 34m
    $592–1,293

  4. Drive 1,264.5 mi

    1. Drive from Jacksonville to La Crossecar car 1,264.5 mi
    22h 51m
    $231–334

  5. Fly Jacksonville to Minneapolis–Saint Paul International Airport, train

    1. Fly from Jacksonville (JAX) to Minneapolis–Saint Paul International Airport (MSP)plane plane JAX - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    9h 25m
    $194–791

  6. Fly Jacksonville to Dane County Regional Airport-Truax Field, bus

    1. Fly from Jacksonville (JAX) to Dane County Regional Airport-Truax Field (MSN)plane plane JAX - MSN
    2. Take the bus from Madison to UW La Crossebus bus
    10h 34m
    $199–860

  7. Drive to Orlando Sanford, fly to La Crosse

    1. Drive from Jacksonville to Orlando-Sanford-Airport-SFBcar car
    2. Fly from Orlando Sanford (SFB) to La Crosse (LSE)plane plane SFB - LSE
    5h 52m
    $142–546

Jacksonville to La Crosse by bus and train (Amtrak)

Calendar7Weekly Services
Duration42h 34mAverage Duration
Ticket$592Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to La Crosse.ExpandLaunch map view
  • Distance: 1,086.5 mi
  • Duration: 7h 26m

What companies run services between Jacksonville, FL, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Jacksonville (JAX) to La Crosse (LSE) 3 times a day. Alternatively, you can take a bus from Jacksonville to La Crosse via Atlanta Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, and Milwaukee in around 31h.

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