Rome2Rio

How to get fromJacksonville to Louisvilleby plane, bus (Flixbus, Greyhound), car, bus, or bus (Greyhound)

Find Transport to Louisville

See all options

There are 8 ways to get from Jacksonville to Louisville by plane, bus (Flixbus, Greyhound), car, bus, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Jacksonville to Louisville International Airport

    best
    1. Fly from Jacksonville (JAX) to Louisville International Airport (SDF)plane plane JAX - SDF
    6h 34m
    $283–606

  2. Fly Jacksonville to Nashville, bus

    cheapest
    1. Fly from Jacksonville (JAX) to Nashville (BNA)plane plane JAX - BNA
    2. Take the bus from Nashville Bus Station to Louisville Bus Stationbus bus
    7h 43m
    $106–490

  3. Bus

    1. Take the bus from Jacksonville to Atlanta Bus Stationbus bus FlixBus 2434 / ...
    2. Take the bus from Atlanta Bus Station to Louisville Bus Stationbus bus Greyhound US0105 / ...
    16h 38m
    $126–245

  4. Drive 685 mi

    1. Drive from Jacksonville to Louisvillecar car 685 mi
    13h 35m
    $125–181

  5. Fly Jacksonville to Blue Grass Airport, drive

    1. Fly from Jacksonville (JAX) to Blue Grass Airport (LEX)plane plane JAX - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    6h 36m
    $175–922

  6. Fly Jacksonville to Covington, bus

    1. Fly from Jacksonville (JAX) to Covington (CVG)plane plane JAX - CVG
    2. Take the bus from Cincinnati to Louisvillebus bus
    7h 33m
    $133–700

  7. Bus to Gainesville Regional Airport, fly to Louisville International Airport

    1. Take the bus from Jacksonville to Gainesvillebus bus
    2. Fly from Gainesville Regional Airport (GNV) to Louisville International Airport (SDF)plane plane GNV - SDF
    8h 55m
    $109–573

  8. Bus via Tallahassee

    1. Take the bus from Jacksonville to Tallahasseebus bus
    2. Take the bus from Tallahassee to Montgomery Intermodal Centerbus bus
    3. Take the bus from Montgomery Intermodal Center to Louisville Bus Stationbus bus
    20h 45m
    $131–259

Jacksonville to Louisville by bus

Calendar55Weekly Buses
Duration16h 38mAverage Duration
Ticket$126Cheapest Price
See schedules

Questions & Answers

Map of how to get from Jacksonville to Louisville.ExpandLaunch map view
  • Distance: 602 mi
  • Duration: 6h 34m

What companies run services between Jacksonville, FL, USA and Louisville, KY, USA?

Delta, American Airlines, and two other airlines fly from Jacksonville (JAX) to Louisville International Airport (SDF) every 2 hours. Alternatively, you can take a bus from Jacksonville to Louisville Bus Station via Atlanta Bus Station in around 16h 38m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers