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How to get fromJacksonville to Mayo Clinicby plane, bus (Flixbus, Greyhound), train, bus, or car

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There are 6 ways to get from Jacksonville to Mayo Clinic by plane, bus (Flixbus, Greyhound), train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Rochester

    best
    1. Fly from Jacksonville (JAX) to Rochester (RST)plane plane JAX - RST
    8h 47m
    $123–593

  2. Bus

    1. Take the bus from Jacksonville to Atlanta Bus Stationbus bus
    2. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    4. Take the bus from Milwaukee to Rochesterbus bus
    33h 8m
    $252–447

  3. Train, bus via Madison

    1. Take the train from Jacksonville to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    46h 42m
    $577–1,233

  4. Drive 1,309.4 mi

    1. Drive from Jacksonville to Mayo Cliniccar car 1,309.4 mi
    23h 24m
    $239–346

  5. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Jacksonville (JAX) to Minneapolis–Saint Paul International Airport (MSP)plane plane JAX - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 50m
    $204–755

  6. Train, bus

    1. Take the train from Jacksonville to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    47h 44m
    $660–1,413

Jacksonville to Mayo Clinic by bus, train, and foot

Calendar7Weekly Services
Duration47h 44mAverage Duration
Ticket$660Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to Mayo Clinic.ExpandLaunch map view
  • Distance: 1,124.9 mi
  • Duration: 8h 47m

What companies run services between Jacksonville, FL, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Jacksonville (JAX) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Jacksonville to Mayo Clinic via Atlanta Bus Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 33h 8m.

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