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How to get fromJacksonville to Sanibel Islandby bus (Flixbus), train, bus, car, plane, or bus (Amtrak)

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There are 8 ways to get from Jacksonville to Sanibel Island by bus (Flixbus), train, bus, car, plane, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Jacksonville to Gainesvillebus bus
    2. Take the bus from Gainesville to University of South Floridabus bus
    3. Take the bus from University of South Florida - 3801 USF Holly Dr to Fort Myers 7-11bus bus
    8h 44m
    $130–208

  2. Drive 309.4 mi

    cheapest
    1. Drive from Jacksonville to Sanibel Islandcar car 309.4 mi
    5h 57m
    $57–82

  3. Train, bus

    1. Take the train from Jacksonville to Tampatrain train Floridian
    2. Take the bus from Tampa Bus Station to Fort Myers Bus Stopbus bus FlixBus 2421
    11h 44m
    $157–272

  4. Fly to Ft. Myers

    1. Fly from Jacksonville (JAX) to Ft. Myers (RSW)plane plane JAX - RSW
    6h 24m
    $387–893

  5. Bus via Orlando (Flixbus)

    1. Take the bus from Jacksonville to Orlando Bus Stationbus bus FlixBus 2433 / ...
    2. Take the bus from Orlando Bus Station to Fort Myers Bus Stopbus bus FlixBus 2421
    10h 38m
    $99–155

  6. Bus #2

    1. Take the bus from Jacksonville to Wildwood Amtrak Stationbus bus Amtrak Thruway Connecting Service
    2. Take the bus from Wildwood to Fort Myersbus bus Houston
    11h 19m
    $167–223

  7. Fly to Fort Lauderdale–Hollywood International Airport, bus

    1. Fly from Jacksonville (JAX) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane JAX - FLL
    2. Take the bus from Fort Lauderdale International Airport to Fort Myers Bus Stopbus bus
    7h 12m
    $198–708

  8. Fly to Miami International Airport, bus

    1. Fly from Jacksonville (JAX) to Miami International Airport (MIA)plane plane JAX - MIA
    2. Take the bus from Miami Airport to Fort Myers 7-11bus bus
    7h 41m
    $167–523

Jacksonville (JAX) to Ft. Myers (RSW) flights

Calendar70Weekly Planes
Duration5h 20mAverage Duration
Ticket$101Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to Sanibel Island.ExpandLaunch map view
  • Distance: 346.6 mi
  • Duration: 8h 44m

What companies run services between Jacksonville, FL, USA and Sanibel Island, FL, USA?

You can take a bus from Jacksonville to Sanibel Island via Gainesville, University of South Florida - 3801 USF Holly Dr, and Fort Myers 7-11 in around 8h 44m. Alternatively, Delta, American Airlines, and two other airlines fly from Jacksonville (JAX) to Ft. Myers (RSW) every 3 hours.

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