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How to get fromJacksonville to Santeeby bus, taxi, train, car, plane, or bus (Flixbus, Greyhound)

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There are 7 ways to get from Jacksonville to Santee by bus, taxi, train, car, plane, or bus (Flixbus, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, taxi (Greyhound)

    best
    1. Take the bus from Jacksonville to Walterboro, SCbus bus Greyhound US0644S
    2. Take the taxi from Walterboro, SC to Santeetaxi taxi
    4h 20m
    $133–183

  2. Drive 240.4 mi

    cheapest
    1. Drive from Jacksonville to Santeecar car 240.4 mi
    3h 56m
    $44–64

  3. Train, drive (Amtrak)

    1. Take the train from Jacksonville to Charleston Amtrak Stationtrain train Silver Meteor
    2. Drive from Charleston Amtrak Station to Santeecar car
    6h 38m
    $92–189

  4. Fly to Columbia, drive

    1. Fly from Jacksonville (JAX) to Columbia (CAE)plane plane JAX - CAE
    2. Drive from Columbia-Airport-CAE to Santeecar car
    6h 14m
    $172–969

  5. Bus

    1. Take the bus from Jacksonville to Orangeburgbus bus FlixBus 2433
    4h 53m
    $118–171

  6. Fly to Charleston International Airport, drive

    1. Fly from Jacksonville (JAX) to Charleston International Airport (CHS)plane plane JAX - CHS
    2. Drive from Charleston-Airport-CHS to Santeecar car
    6h 13m
    $82–429

  7. Fly to Augusta Regional Airport At Bush Field, drive

    1. Fly from Jacksonville (JAX) to Augusta Regional Airport At Bush Field (AGS)plane plane JAX - AGS
    2. Drive from Augusta Regional Airport At Bush Field (AGS) to Santeecar car
    7h 26m
    $80–410

Jacksonville (JAX) to Columbia (CAE) flights

Calendar84Weekly Planes
Duration4h 39mAverage Duration
Ticket$162Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to Santee.ExpandLaunch map view
  • Distance: 246.6 mi
  • Duration: 4h 20m

What companies run services between Jacksonville, FL, USA and Santee, SC, USA?

Flixbus USA operates a bus from Jacksonville to Orangeburg once daily. Tickets cost $40–70 and the journey takes 4h 25m. Greyhound USA also services this route once daily.

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