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How to get fromJacksonville to St. Louisby plane, bus (Flixbus, Greyhound), or car

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There are 3 ways to get from Jacksonville to St. Louis by plane, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL)plane plane JAX - STL
    4h 44m
    $145–706

  2. Bus

    1. Take the bus from Jacksonville to Atlanta Bus Stationbus bus FlixBus 2434 / ...
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    19h 20m
    $145–283

  3. Drive 861.3 mi

    1. Drive from Jacksonville to St. Louiscar car 861.3 mi
    15h 15m
    $158–227

Jacksonville to St. Louis by bus

Calendar12Weekly Buses
Duration19h 20mAverage Duration
Ticket$145Cheapest Price
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Questions & Answers

Map of how to get from Jacksonville to St. Louis.ExpandLaunch map view
  • Distance: 783.5 mi
  • Duration: 4h 44m

What companies run services between Jacksonville, FL, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and American Airlines fly from Jacksonville (JAX) to Lambert–St. Louis International Airport (STL) 5 times a day. Alternatively, you can take a bus from Jacksonville to St Louis Bus Station via Atlanta Bus Station in around 19h 20m.

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