There are 4 ways to get from Jacksonville to Tupelo by plane, car, or bus (Flixbus, Greyhound)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly to Golden Triangle Regional Airport, drive
best- Fly from Jacksonville (JAX) to Golden Triangle Regional Airport (GTR)plane JAX - GTR
- Drive from Golden Triangle Regional Airport (GTR) to Tupelocar
6h 44m$68–360Bus
- Take the bus from Jacksonville to Atlanta Bus Stationbus FlixBus 2434 / ...
- Take the bus from Atlanta Bus Station to Tupelobus Greyhound US0610
13h 39m$108–179Drive 544.6 mi
- Drive from Jacksonville to Tupelocar 544.6 mi
10h 17m$100–144Fly to Huntsville International Airport-Carl T Jones Field, drive
- Fly from Jacksonville (JAX) to Huntsville International Airport-Carl T Jones Field (HSV)plane JAX - HSV
- Drive from Huntsville International Airport-Carl T Jones Field (HSV) to Tupelocar
7h 48m$95–458
Jacksonville (JAX) to Golden Triangle Regional Airport (GTR) flights
Comparing Your Travel Options
The cheapest way to get from Jacksonville to Tupelo is to drive which costs $95 - $150 and takes 10h 17m.
The fastest way to get from Jacksonville to Tupelo is to fly and drive which takes 6h 44m and costs $65 - $360.
No, there is no direct bus from Jacksonville to Tupelo. However, there are services departing from Jacksonville and arriving at Tupelo via Atlanta Bus Station. The journey, including transfers, takes approximately 13h 39m.
The distance between Jacksonville and Tupelo is 535 miles. The road distance is 547.8 miles.
The best way to get from Jacksonville to Tupelo without a car is to bus which takes 13h 39m and costs $100 - $180.
It takes approximately 6h 44m to get from Jacksonville to Tupelo, including transfers.
Jacksonville to Tupelo bus services, operated by Flixbus USA, depart from Jacksonville station.
Jacksonville to Tupelo bus services, operated by Flixbus USA, arrive at Atlanta Bus Station.
Tupelo is 1h behind Jacksonville. It is currently 12:57 AM in Jacksonville and 11:57 PM in Tupelo.
Yes, the driving distance between Jacksonville to Tupelo is 548 miles. It takes approximately 10h 17m to drive from Jacksonville to Tupelo.
What companies run services between Jacksonville, FL, USA and Tupelo, MS, USA?
You can take a bus from Jacksonville to Tupelo via Atlanta Bus Station and Tupelo in around 13h 39m.
- Website
- delta.com
Flights from Jacksonville to Golden Triangle Regional Airport via Atlanta
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- $55–360
Flights from Jacksonville to Huntsville International Airport-Carl T Jones Field via Atlanta
- Ave. Duration
- 3h 48m
- When
- Every day
- Estimated price
- $70–420
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Jacksonville to Atlanta Bus Station
- Ave. Duration
- 6h 40m
- Frequency
- 3 times a day
- Estimated price
- $55–90
- Schedules at
- Flixbus USA
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Booking & Getting There
Book your Jacksonville to Tupelo bus tickets online with Omio.
There are 33+ hotels available in Tupelo.

