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How to get fromJacksonville to Winston-Salemby bus (Flixbus, Greyhound), train, bus, car, plane, or bus (Greyhound)

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There are 8 ways to get from Jacksonville to Winston-Salem by bus (Flixbus, Greyhound), train, bus, car, plane, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Jacksonville to Charlotte Bus Stationbus bus FlixBus 2433
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus Greyhound US0670
    9h 30m
    $74–123

  2. Fly Jacksonville to Piedmont Triad International Airport

    cheapest
    1. Fly from Jacksonville (JAX) to Piedmont Triad International Airport (GSO)plane plane JAX - GSO
    6h 22m
    $71–346

  3. Train, bus

    1. Take the train from Jacksonville to Carytrain train
    2. Take the train from Cary to Greensborotrain train
    3. Take the bus from Greensboro Bus Stop to Winston Salem(Trans Center)bus bus
    13h 56m
    $318–499

  4. Drive  457.6 mi

    1. Drive from Jacksonville to Winston-Salemcar car 457.6 mi
    7h 40m
    $79–113

  5. Bus via Camden (Greyhound)

    1. Take the bus from Jacksonville to Camdenbus bus
    2. Take the bus from Camden to Charlotte Bus Stationbus bus
    3. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    12h 5m
    $87–131

  6. Fly Jacksonville to Charlotte Douglas International Airport, bus

    1. Fly from Jacksonville (JAX) to Charlotte Douglas International Airport (CLT)plane plane JAX - CLT
    2. Take the bus from Charlotte Bus Station to Winston Salem(Trans Center)bus bus
    6h 35m
    $89–490

  7. Fly Jacksonville to Raleigh-Durham International Airport, bus

    1. Fly from Jacksonville (JAX) to Raleigh-Durham International Airport (RDU)plane plane JAX - RDU
    2. Take the bus from Durham to Winston Salem(Trans Center)bus bus
    7h 43m
    $97–491

  8. Bus to Gainesville Regional Airport, fly to Piedmont Triad International Airport

    1. Take the bus from Jacksonville to Gainesvillebus bus
    2. Fly from Gainesville Regional Airport (GNV) to Piedmont Triad International Airport (GSO)plane plane GNV - GSO
    8h 37m
    $92–401

Jacksonville to Winston-Salem by bus

Calendar14Weekly Buses
Duration9h 30mAverage Duration
Ticket$74Cheapest Price
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Comparing Your Travel Options

Map of how to get from Jacksonville to Winston-Salem.ExpandLaunch map view
  • Distance: 457.2 mi
  • Duration: 9h 30m

What companies run services between Jacksonville, FL, USA and Winston-Salem, NC, USA?

You can take a bus from Jacksonville to Winston Salem(Trans Center) via Charlotte Bus Station in around 9h 30m. Alternatively, American Airlines, Delta, and United Airlines fly from Jacksonville (JAX) to Piedmont Triad International Airport (GSO) hourly.

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Need to know: Greyhound

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