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How to get fromJefferson City to Buffaloby plane, train (Amtrak), bus (Greyhound), car, bus, shuttle, or train

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There are 9 ways to get from Jefferson City to Buffalo by plane, train (Amtrak), bus (Greyhound), car, bus, shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Columbia Regional Airport to Buffalo Niagara International Airport

    best
    1. Fly from Columbia Regional Airport (COU) to Buffalo Niagara International Airport (BUF)plane plane COU - BUF
    6h 12m
    $213–826

  2. Drive 858 mi

    cheapest
    1. Drive from Jefferson City to Buffalocar car 858 mi
    14h 52m
    $157–227

  3. Train (Amtrak)

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train Lincoln Service Missouri River Runner
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    20h 55m
    $303–752

  4. Bus

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Columbusbus bus
    3. Take the bus from Columbus - Mound St to Buffalo, NYbus bus
    22h 38m
    $189–340

  5. Fly Columbia Regional Airport to Rochester, bus

    1. Fly from Columbia Regional Airport (COU) to Rochester (ROC)plane plane COU - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 9m
    $251–841

  6. Shuttle to Lambert–St. Louis International Airport, fly to Buffalo Niagara International Airport

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    7h 18m
    $298–1,025

  7. Fly Columbia Regional Airport to Toronto Pearson International Airport, shuttle

    1. Fly from Columbia Regional Airport (COU) to Toronto Pearson International Airport (YYZ)plane plane COU - YYZ
    2. Take a shuttle bus from Pearson International Airport Terminal 1 to Buffalo Airportshuttle bus
    8h 25m
    $239–559

  8. Fly Columbia Regional Airport to Toronto Island Airport, train

    1. Fly from Columbia Regional Airport (COU) to Toronto Island Airport (YTZ)plane plane COU - YTZ
    2. Take the train from Toronto Union Station to Buffalotrain train
    10h 20m
    $181–627

  9. Train, bus

    1. Take the train from Jefferson City Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    25h 18m
    $180–459

Jefferson City to Buffalo by train (Amtrak)

Calendar7Weekly Trains
Duration20h 55mAverage Duration
Ticket$303Cheapest Price
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Questions & Answers

Map of how to get from Jefferson City to Buffalo.ExpandLaunch map view
  • Distance: 793.3 mi
  • Duration: 6h 12m

What companies run services between Jefferson City, MO, USA and Buffalo, NY, USA?

United Airlines and American Airlines fly from Columbia Regional Airport (COU) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a train from Jefferson City Station to Buffalo via Chicago Union Station and Buffalo Depew Station in around 20h 55m.

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