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How to get fromJefferson City to Buffaloby plane, train (Amtrak), bus (Greyhound), car, bus, shuttle, or train

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There are 9 ways to get from Jefferson City to Buffalo by plane, train (Amtrak), bus (Greyhound), car, bus, shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Columbia Regional Airport to Buffalo Niagara International Airport

    best
    1. Fly from Columbia Regional Airport (COU) to Buffalo Niagara International Airport (BUF)plane plane COU - BUF
    5h 52m
    $193–700

  2. Bus

    cheapest
    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis, IN to Toledobus bus
    4. Take the bus from Toledo to Clevelandbus bus
    5. Take the bus from Cleveland, OH to Buffalo, NYbus bus
    21h 18m
    $120–285

  3. Train (Amtrak)

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train Lincoln Service Missouri River Runner
    2. Take the train from Chicago Union Station to Buffalo Depew Stationtrain train Lake Shore Limited
    20h 55m
    $239–682

  4. Drive  858 mi

    1. Drive from Jefferson City to Buffalocar car 858 mi
    14h 52m
    $157–227

  5. Fly Columbia Regional Airport to Rochester, bus

    1. Fly from Columbia Regional Airport (COU) to Rochester (ROC)plane plane COU - ROC
    2. Take the bus from Rochester Bus Stop to Buffalobus bus
    7h 30m
    $261–938

  6. Fly Columbia Regional Airport to Toronto Pearson International Airport, bus

    1. Fly from Columbia Regional Airport (COU) to Toronto Pearson International Airport (YYZ)plane plane COU - YYZ
    2. Take the bus from Toronto Pearson Airport to Buffalobus bus
    9h 1m
    $167–490

  7. Shuttle to Lambert–St. Louis International Airport, fly to Buffalo Niagara International Airport

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Buffalo Niagara International Airport (BUF)plane plane STL - BUF
    7h 45m
    $258–849

  8. Fly Columbia Regional Airport to Toronto Island Airport, bus, train

    1. Fly from Columbia Regional Airport (COU) to Toronto Island Airport (YTZ)plane plane COU - YTZ
    2. Take the bus from Union Stn Bus Terminal, 81 Bay St at Lakeshore Blvd, 2nd Floor to Bus Terminalbus bus
    3. Take the train from Niagara Falls Amtrak Station to Buffalotrain train
    8h 56m
    $165–672

  9. Train, bus

    1. Take the train from Jefferson City Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Pittsburgh Intermodal Stationbus bus
    3. Take the bus from Pittsburgh, Pa to Buffalo, Nybus bus 510
    27h 3m
    $172–410

Jefferson City to Buffalo by train (Amtrak)

Calendar7Weekly Trains
Duration20h 55mAverage Duration
Ticket$239Cheapest Price
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Questions & Answers

Map of how to get from Jefferson City to Buffalo.ExpandLaunch map view
  • Distance: 789.1 mi
  • Duration: 5h 52m

What companies run services between Jefferson City, MO, USA and Buffalo, NY, USA?

American Airlines and United Airlines fly from Columbia Regional Airport (COU) to Buffalo Niagara International Airport (BUF) every 4 hours. Alternatively, you can take a train from Jefferson City Station to Buffalo via Chicago Union Station and Buffalo Depew Station in around 20h 55m.

Airlines
Train operators
Bus operators

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