There are 5 ways to get from Jefferson City to Cape Girardeau by train, bus, bus (Greyhound), car, plane, or taxi
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train, bus
best- Take the train from Jefferson City Station to St. Louistrain Missouri River Runner / ...
- Take the bus from St Louis Bus Station to Cape Girardeaubus Greyhound US1173
5h 42m$63–124Drive 202.5 mi
cheapest- Drive from Jefferson City to Cape Girardeaucar 202.5 mi
4h 9m$37–54Bus (Greyhound)
- Take the bus from Jefferson City to St Louis Bus Stationbus Greyhound US0175s
- Take the bus from St Louis Bus Station to Cape Girardeaubus Greyhound US1173
6h 52m$58–104Fly to Williamson County Regional Airport, taxi
- Fly from Columbia Regional Airport (COU) to Williamson County Regional Airport (MWA)plane COU - MWA
- Take the taxi from Williamson County Regional Airport (MWA) to Cape Girardeautaxi
5h 31m$277–617Fly to Barkley Regional Airport, taxi
- Fly from Columbia Regional Airport (COU) to Barkley Regional Airport (PAH)plane COU - PAH
- Take the taxi from Barkley Regional Airport (PAH) to Cape Girardeautaxi
8h 48m$292–647
Columbia Regional Airport (COU) to Williamson County Regional Airport (MWA) flights
Questions & Answers
The cheapest way to get from Jefferson City to Cape Girardeau is to drive which costs $35 - $55 and takes 4h 9m.
The fastest way to get from Jefferson City to Cape Girardeau is to drive which takes 4h 9m and costs $35 - $55.
No, there is no direct bus from Jefferson City to Cape Girardeau. However, there are services departing from Jefferson City and arriving at Cape Girardeau via St Louis Bus Station. The journey, including transfers, takes approximately 6h 52m.
The distance between Jefferson City and Cape Girardeau is 239 miles. The road distance is 203.7 miles.
The best way to get from Jefferson City to Cape Girardeau without a car is to train and bus which takes 5h 42m and costs $60 - $130.
It takes approximately 5h 42m to get from Jefferson City to Cape Girardeau, including transfers.
Jefferson City to Cape Girardeau bus services, operated by Greyhound USA, depart from Jefferson City station.
Jefferson City to Cape Girardeau bus services, operated by Greyhound USA, arrive at St Louis Bus Station.
Yes, the driving distance between Jefferson City to Cape Girardeau is 204 miles. It takes approximately 4h 9m to drive from Jefferson City to Cape Girardeau.
Book your Jefferson City to Cape Girardeau bus tickets online with Omio.
What companies run services between Jefferson City, MO, USA and Cape Girardeau, MO, USA?
You can take a vehicle from Jefferson City to Cape Girardeau via Jefferson City, St Louis Bus Station, and Cape Girardeau in around 6h 52m.
- Website
- contouraviation.com
Flights from Columbia Regional Airport to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 6h 4m
- When
- Every day
- Estimated price
- $65–360
- Website
- united.com
Flights from Columbia Regional Airport to Barkley Regional Airport via Chicago O'Hare
- Ave. Duration
- 7h 2m
- When
- Every day
- Estimated price
- $70–380
- Website
- aa.com
Flights from Columbia Regional Airport to Williamson County Regional Airport via Chicago O'Hare
- Ave. Duration
- 3h 57m
- When
- Every day
- Estimated price
- $65–360
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- Amtrak
Train from Jefferson City Station to St. Louis
- Ave. Duration
- 2h 33m
- Frequency
- Twice daily
- Estimated price
- $35–80
- Website
- Amtrak
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Twice daily
- Estimated price
- $17–35
- Website
- Greyhound
Bus from Jefferson City to St Louis Bus Station
- Ave. Duration
- 3h 40m
- Frequency
- Twice daily
- Estimated price
- $25–50
- Website
- Greyhound
Bus from St Louis Bus Station to Cape Girardeau
- Ave. Duration
- 2h 5m
- Frequency
- Twice daily
- Estimated price
- $17–35
- Website
- Greyhound
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More Questions & Answers
There are 20+ hotels available in Cape Girardeau.






