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How to get fromJefferson City to Des Moinesby bus (Greyhound), train, bus, car, plane, or shuttle

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There are 6 ways to get from Jefferson City to Des Moines by bus (Greyhound), train, bus, car, plane, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus (Greyhound)

    best
    1. Take the bus from Jefferson City to Kansas City Bus Stationbus bus Greyhound US0175s
    2. Take the bus from Kansas City Bus Station to Des Moinesbus bus Greyhound US0156
    7h 18m
    $71–110

  2. Drive  254.9 mi

    cheapest
    1. Drive from Jefferson City to Des Moinescar car 254.9 mi
    5h 12m
    $44–63

  3. Train, bus

    1. Take the train from Jefferson City Station to Kansas Citytrain train Missouri River Runner / ...
    2. Take the bus from Kansas City Bus Station to Des Moinesbus bus Greyhound US0156
    8h 12m
    $122–188

  4. Fly from Columbia Regional Airport

    1. Fly from Columbia Regional Airport (COU) to Des Moines (DSM)plane plane COU - DSM
    4h 51m
    $165–500

  5. Train, bus via Des Moines

    1. Take the train from Jefferson City Station to Kansas Citytrain train Missouri River Runner / ...
    2. Take the bus from Kansas City to Des Moinesbus bus Jefferson Lines 804 / ...
    8h 26m
    $137–208

  6. Shuttle to Lambert–St. Louis International Airport, fly

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Des Moines (DSM)plane plane STL - DSM
    7h 2m
    $225–599

Jefferson City to Des Moines by train, foot, and bus

Calendar7Weekly Services
Duration8h 12mAverage Duration
Ticket$122Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Jefferson City to Des Moines.ExpandLaunch map view
  • Distance: 346.4 mi
  • Duration: 7h 18m

What companies run services between Jefferson City, MO, USA and Des Moines, IA, USA?

You can take a vehicle from Jefferson City to Des Moines via Jefferson City and Kansas City Bus Station in around 7h 18m. Alternatively, United Airlines and American Airlines fly from Columbia Regional Airport (COU) to Des Moines (DSM) every 4 hours.

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Bus operators

Want to know more about travelling around United States

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Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

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