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How to get fromJefferson City to Greenvilleby plane, train, bus, car, taxi, shuttle, or bus (Greyhound, Flixbus)

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There are 7 ways to get from Jefferson City to Greenville by plane, train, bus, car, taxi, shuttle, or bus (Greyhound, Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Columbia Regional Airport to Greenville–Spartanburg International Airport

    best
    1. Fly from Columbia Regional Airport (COU) to Greenville–Spartanburg International Airport (GSP)plane plane COU - GSP
    5h 37m
    $227–742

  2. Drive 745.4 mi

    cheapest
    1. Drive from Jefferson City to Greenvillecar car 745.4 mi
    13h 56m
    $136–197

  3. Train, bus via Carbondale

    1. Take the train from Jefferson City Station to St. Louistrain train
    2. Take the bus from St. Louis to Carbondalebus bus
    3. Take the bus from Carbondale Intermodal Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    19h 55m
    $180–416

  4. Fly Columbia Regional Airport to Asheville Regional Airport, taxi

    1. Fly from Columbia Regional Airport (COU) to Asheville Regional Airport (AVL)plane plane COU - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    5h 47m
    $297–677

  5. Shuttle to Lambert–St. Louis International Airport, fly to Greenville–Spartanburg International Airport

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Greenville–Spartanburg International Airport (GSP)plane plane STL - GSP
    6h 28m
    $282–891

  6. Train, bus

    1. Take the train from Jefferson City Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    20h 30m
    $181–411

  7. Bus

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta to Taqueria Guadalajara - Greenvillebus bus
    21h 56m
    $180–395

Columbia Regional Airport (COU) to Greenville–Spartanburg International Airport (GSP) flights

Calendar41Weekly Planes
Duration6h 17mAverage Duration
Ticket$113Cheapest Price
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Questions & Answers

Map of how to get from Jefferson City to Greenville.ExpandLaunch map view
  • Distance: 648.2 mi
  • Duration: 5h 37m

What companies run services between Jefferson City, MO, USA and Greenville, SC, USA?

American Airlines and United Airlines fly from Columbia Regional Airport (COU) to Greenville–Spartanburg International Airport (GSP) every 4 hours. Alternatively, you can take a vehicle from Jefferson City to Greenville via Jefferson City, St Louis Bus Station, Atlanta Bus Station, Garnett Station, Lindbergh Center Station, Lindbergh Center Station - Bay D, Shallowford Rd @ New Peachtree, Atlanta, and Taqueria Guadalajara - Greenville in around 21h 56m.

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