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How to get fromJefferson City to Indianapolisby train, bus, train (Amtrak), car, plane, bus (Greyhound), or shuttle

Find Transport to Indianapolis

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There are 7 ways to get from Jefferson City to Indianapolis by train, bus, train (Amtrak), car, plane, bus (Greyhound), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Jefferson City Station to St. Louistrain train Missouri River Runner / ...
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    8h 18m
    $107–168

  2. Drive  362.9 mi

    cheapest
    1. Drive from Jefferson City to Indianapoliscar car 362.9 mi
    6h 17m
    $67–96

  3. Train (Amtrak)

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train Lincoln Service Missouri River Runner
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    14h 5m
    $323–512

  4. Fly Columbia Regional Airport to Indianapolis

    1. Fly from Columbia Regional Airport (COU) to Indianapolis (IND)plane plane COU - IND
    5h 34m
    $169–599

  5. Bus (Greyhound)

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus Greyhound US0175s
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    9h 28m
    $79–120

  6. Shuttle to Lambert–St. Louis International Airport, fly to Indianapolis

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    7h 36m
    $999–1,048

  7. Fly Columbia Regional Airport to Purdue University Airport, bus

    1. Fly from Columbia Regional Airport (COU) to Purdue University Airport (LAF)plane plane COU - LAF
    2. Take the bus from Lafayette Amtrak Station to Indianapolis Union Stationbus bus
    7h 58m
    $152–493

Jefferson City to Indianapolis by train and bus

Calendar14Weekly Services
Duration8h 18mAverage Duration
Ticket$107Cheapest Price
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Comparing Your Travel Options

Map of how to get from Jefferson City to Indianapolis.ExpandLaunch map view
  • Distance: 364.4 mi
  • Duration: 8h 18m

What companies run services between Jefferson City, MO, USA and Indianapolis, IN, USA?

You can take a train from Jefferson City Station to Indianapolis via Chicago Union Station in around 14h 5m. Alternatively, United Airlines, American Airlines, and Allegiant Air fly from Columbia Regional Airport (COU) to Indianapolis (IND) every 2 hours.

Airlines
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Bus operators

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