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How to get fromJefferson City to Indianapolisby train, bus, car, plane, bus (Greyhound), train (Amtrak), or shuttle

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There are 8 ways to get from Jefferson City to Indianapolis by train, bus, car, plane, bus (Greyhound), train (Amtrak), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Jefferson City Station to St. Louistrain train Missouri River Runner / ...
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    7h 58m
    $75–154

  2. Drive 362.9 mi

    cheapest
    1. Drive from Jefferson City to Indianapoliscar car 362.9 mi
    6h 17m
    $67–96

  3. Train, bus via Bloomington

    1. Take the train from Jefferson City Station to Bloomington-Normaltrain train Lincoln Service Missouri River Runner
    2. Take the bus from Bloomington to Indianapolisbus bus Btw 1402
    9h 48m

  4. Fly Columbia Regional Airport to Indianapolis

    1. Fly from Columbia Regional Airport (COU) to Indianapolis (IND)plane plane COU - IND
    5h 32m
    $169–579

  5. Bus

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus Greyhound US0175s
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus Greyhound US0421
    9h 8m
    $71–140

  6. Train (Amtrak)

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train Lincoln Service Missouri River Runner
    2. Take the train from Chicago Union Station to Indianapolistrain train Cardinal
    14h 5m
    $191–392

  7. Shuttle to Lambert–St. Louis International Airport, fly to Indianapolis

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Indianapolis (IND)plane plane STL - IND
    7h 26m
    $239–748

  8. Fly Columbia Regional Airport to Purdue University Airport, train

    1. Fly from Columbia Regional Airport (COU) to Purdue University Airport (LAF)plane plane COU - LAF
    2. Take the train from Lafayette Amtrak Station to Indianapolistrain train
    9h 45m
    $162–478

Jefferson City to Indianapolis by train and bus

Calendar14Weekly Services
Duration7h 58mAverage Duration
Ticket$75Cheapest Price
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Questions & Answers

Map of how to get from Jefferson City to Indianapolis.ExpandLaunch map view
  • Distance: 363.6 mi
  • Duration: 7h 58m

What companies run services between Jefferson City, MO, USA and Indianapolis, IN, USA?

United Airlines and American Airlines fly from Columbia Regional Airport (COU) to Indianapolis (IND) every 4 hours. Alternatively, you can take a vehicle from Jefferson City to Indianapolis Union Station via Jefferson City and St Louis Bus Station in around 9h 8m.

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