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How to get fromJefferson City to Key Westby plane, bus (Greyhound, Flixbus), train, bus, car, shuttle, or ferry

Find Transport to Key West

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There are 6 ways to get from Jefferson City to Key West by plane, bus (Greyhound, Flixbus), train, bus, car, shuttle, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbia Regional Airport

    best
    1. Fly from Columbia Regional Airport (COU) to Key West International Airport (EYW)plane plane COU - EYW
    6h 18m
    $183–530

  2. Bus

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    3. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    4. Take the bus from Miami Airport Station to Big Pine Keybus bus
    5. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    37h 50m
    $258–434

  3. Train, bus

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Miami Amtrak Stationtrain train
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    4. Take the bus from Big Pine Key - CVS / MM30 to N Roosevelt & 3rd Streetbus bus Lks
    2d 14h
    $1,365–2,203

  4. Drive  1,447.5 mi

    1. Drive from Jefferson City to Key Westcar car 1,447.5 mi
    26h 36m
    $265–382

  5. Shuttle to Lambert–St. Louis International Airport, fly

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Key West International Airport (EYW)plane plane STL - EYW
    7h 41m
    $238–599

  6. Train, bus, ferry

    1. Take the train from Jefferson City Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to New Orleans Bus Stationbus bus
    3. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    4. Take the bus from Gulfport to Fort Myersbus bus
    5. Take the ferry from Fort Myers Beach, FL to Key West, FLferry ferry
    42h 5m
    $517–693

Jefferson City to Key West by train, taxi, bus, and foot

Calendar7Weekly Services
Duration2d 14hAverage Duration
Ticket$1,365Cheapest Price
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Comparing Your Travel Options

Map of how to get from Jefferson City to Key West.ExpandLaunch map view
  • Distance: 1,182.3 mi
  • Duration: 6h 18m

What companies run services between Jefferson City, MO, USA and Key West, FL, USA?

American Airlines and United Airlines fly from Columbia Regional Airport (COU) to Key West International Airport (EYW) 5 times a day. Alternatively, you can take a vehicle from Jefferson City to N Roosevelt & 3rd Street via Jefferson City, St Louis Bus Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, and Big Pine Key - CVS / MM30 in around 37h 50m.

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