Rome2Rio

How to get fromJefferson City to Knoxvilleby plane, train, bus, car, or shuttle

Find Transport to Knoxville

See all options

There are 6 ways to get from Jefferson City to Knoxville by plane, train, bus, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Columbia Regional Airport

    best
    1. Fly from Columbia Regional Airport (COU) to Mcghee Tyson Airport (TYS)plane plane COU - TYS
    5h 19m
    $277–917

  2. Drive 578.7 mi

    cheapest
    1. Drive from Jefferson City to Knoxvillecar car 578.7 mi
    10h 51m
    $106–153

  3. Train, bus

    1. Take the train from Jefferson City Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h
    $372–633

  4. Train, bus via Chicago

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    3. Take the bus from New York to Knoxvillebus bus Nyc
    42h 56m
    $612–1,167

  5. Shuttle to Lambert–St. Louis International Airport, fly

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Mcghee Tyson Airport (TYS)plane plane STL - TYS
    7h 16m
    $312–966

  6. Train, bus via Chicago #2

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Croton-Harmon Amtrak Stationtrain train
    3. Take the train from Croton-Harmon to 125th Street - Harlemtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    43h 33m
    $567–1,094

Columbia Regional Airport (COU) to Mcghee Tyson Airport (TYS) flights

Calendar63Weekly Planes
Duration5h 18mAverage Duration
Ticket$144Cheapest Price
See schedules

Questions & Answers

Map of how to get from Jefferson City to Knoxville.ExpandLaunch map view
  • Distance: 530.8 mi
  • Duration: 5h 19m

What companies run services between Jefferson City, MO, USA and Knoxville, TN, USA?

American Airlines, United Airlines, and Allegiant Air fly from Columbia Regional Airport (COU) to Mcghee Tyson Airport (TYS) every 3 hours.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound