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How to get fromJefferson City to Lafayetteby plane, bus (Greyhound, Amtrak), train, bus, car, shuttle, or train (Amtrak)

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There are 6 ways to get from Jefferson City to Lafayette by plane, bus (Greyhound, Amtrak), train, bus, car, shuttle, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Purdue University Airport

    best
    1. Fly from Columbia Regional Airport (COU) to Purdue University Airport (LAF)plane plane COU - LAF
    6h 49m
    $138–438

  2. Drive 369 mi

    cheapest
    1. Drive from Jefferson City to Lafayettecar car 369 mi
    6h 38m
    $68–98

  3. Bus

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Lafayette Amtrak Stationbus bus
    11h 28m
    $83–175

  4. Train, bus (Amtrak)

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train Lincoln Service Missouri River Runner
    2. Take the bus from Chicago Union Station to Lafayette Amtrak Stationbus bus Chicago
    11h 41m
    $147–307

  5. Fly to Indianapolis, shuttle

    1. Fly from Columbia Regional Airport (COU) to Indianapolis (IND)plane plane COU - IND
    2. Take a shuttle bus from Indianapolis Airport to Holiday Inn City Centreshuttle bus
    6h 12m
    $176–622

  6. Train (Amtrak)

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train Lincoln Service Missouri River Runner
    2. Take the train from Chicago Union Station to Lafayette Amtrak Stationtrain train Cardinal
    12h 12m
    $159–342

Jefferson City to Lafayette by train and bus (Amtrak)

Calendar7Weekly Services
Duration11h 41mAverage Duration
Ticket$147Cheapest Price
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Questions & Answers

Map of how to get from Jefferson City to Lafayette.ExpandLaunch map view
  • Distance: 325.6 mi
  • Duration: 6h 49m

What companies run services between Jefferson City, MO, USA and Lafayette, IN, USA?

United Airlines and American Airlines fly from Columbia Regional Airport (COU) to Purdue University Airport (LAF) 4 times a day. Alternatively, you can take a vehicle from Jefferson City to Lafayette Amtrak Station via Jefferson City, St Louis Bus Station, and Indianapolis Union Station in around 11h 28m.

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