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How to get fromJefferson City to Lexingtonby plane, car, train, bus, shuttle, or bus (Greyhound)

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There are 8 ways to get from Jefferson City to Lexington by plane, car, train, bus, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Columbia Regional Airport to Louisville International Airport, drive

    best
    1. Fly from Columbia Regional Airport (COU) to Louisville International Airport (SDF)plane plane COU - SDF
    2. Drive from Louisville-Airport-SDF to Lexingtoncar car
    6h 10m
    $191–668

  2. Drive 465.9 mi

    cheapest
    1. Drive from Jefferson City to Lexingtoncar car 465.9 mi
    8h 6m
    $85–123

  3. Train, bus

    1. Take the train from Jefferson City Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Lexington Bus Stopbus bus
    13h

  4. Train, bus via Chicago

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Indianapolistrain train
    3. Take the bus from Indianapolis Union Station to Lexington Bus Stopbus bus
    19h 7m

  5. Fly Columbia Regional Airport to Blue Grass Airport

    1. Fly from Columbia Regional Airport (COU) to Blue Grass Airport (LEX)plane plane COU - LEX
    7h 4m
    $234–899

  6. Shuttle to Lambert–St. Louis International Airport, fly to Blue Grass Airport

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Blue Grass Airport (LEX)plane plane STL - LEX
    9h 24m
    $319–1,148

  7. Bus

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Indianapolis Union Stationbus bus
    3. Take the bus from Indianapolis Union Station to Lexington Bus Stopbus bus
    14h 10m

  8. Train, bus via Bloomington

    1. Take the train from Jefferson City Station to Bloomington-Normaltrain train
    2. Take the bus from Bloomington to Indianapolisbus bus
    3. Take the bus from Indianapolis Union Station to Lexington Bus Stopbus bus
    15h 41m

Columbia Regional Airport (COU) to Louisville International Airport (SDF) flights

Calendar38Weekly Planes
Duration5h 27mAverage Duration
Ticket$96Cheapest Price
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Questions & Answers

Map of how to get from Jefferson City to Lexington.ExpandLaunch map view
  • Distance: 452.8 mi
  • Duration: 6h 10m

What companies run services between Jefferson City, MO, USA and Lexington, KY, USA?

United Airlines and American Airlines fly from Columbia Regional Airport (COU) to Blue Grass Airport (LEX) every 4 hours. Alternatively, you can take a vehicle from Jefferson City to Lexington via Jefferson City, St Louis Bus Station, Indianapolis Union Station, and Lexington Bus Stop in around 14h 10m.

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