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How to get fromJefferson City to Louisvilleby plane, train, bus, car, shuttle, or bus (Greyhound)

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There are 7 ways to get from Jefferson City to Louisville by plane, train, bus, car, shuttle, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Columbia Regional Airport to Louisville International Airport

    best
    1. Fly from Columbia Regional Airport (COU) to Louisville International Airport (SDF)plane plane COU - SDF
    5h 52m
    $178–650

  2. Drive 387.1 mi

    cheapest
    1. Drive from Jefferson City to Louisvillecar car 387.1 mi
    6h 38m
    $71–102

  3. Train, bus

    1. Take the train from Jefferson City Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Louisville, KYbus bus
    10h 13m
    $100–185

  4. Fly Columbia Regional Airport to Blue Grass Airport, drive

    1. Fly from Columbia Regional Airport (COU) to Blue Grass Airport (LEX)plane plane COU - LEX
    2. Drive from Lexington-Airport-LEX to Louisvillecar car
    5h 59m
    $235–916

  5. Shuttle to Lambert–St. Louis International Airport, fly to Louisville International Airport

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Louisville International Airport (SDF)plane plane STL - SDF
    7h 31m
    $238–799

  6. Fly Columbia Regional Airport to Covington, bus

    1. Fly from Columbia Regional Airport (COU) to Covington (CVG)plane plane COU - CVG
    2. Take the bus from Cincinnati - Downtown to Louisville, KY Bus Stationbus bus
    8h 26m
    $193–694

  7. Bus

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Evansville Bus Stationbus bus
    3. Take the bus from Evansville, IN to Louisville, KYbus bus
    11h 23m
    $94–165

Jefferson City to Louisville by train and bus

Calendar7Weekly Services
Duration10h 13mAverage Duration
Ticket$100Cheapest Price
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Questions & Answers

Map of how to get from Jefferson City to Louisville.ExpandLaunch map view
  • Distance: 379.5 mi
  • Duration: 5h 52m

What companies run services between Jefferson City, MO, USA and Louisville, KY, USA?

American Airlines and United Airlines fly from Columbia Regional Airport (COU) to Louisville International Airport (SDF) every 4 hours. Alternatively, you can take a vehicle from Jefferson City to Louisville, KY via Jefferson City, St Louis Bus Station, and Evansville, IN in around 11h 23m.

Airlines
Train operators
Bus operators

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