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How to get fromJefferson City to Mayo Clinicby plane, train, bus, shuttle, bus (Greyhound), or car

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There are 9 ways to get from Jefferson City to Mayo Clinic by plane, train, bus, shuttle, bus (Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Columbia Regional Airport to Rochester

    best
    1. Fly from Columbia Regional Airport (COU) to Rochester (RST)plane plane COU - RST
    5h 37m
    $148–497

  2. Drive 411.2 mi

    cheapest
    1. Drive from Jefferson City to Mayo Cliniccar car 411.2 mi
    8h 20m
    $75–109

  3. Train, bus, shuttle

    1. Take the train from Jefferson City Station to Kansas Citytrain train
    2. Take the bus from Kansas City to Owatonnabus bus
    3. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    14h 17m
    $145–273

  4. Train, bus via Madison

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    18h 17m
    $204–394

  5. Train, bus

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochesterbus bus
    19h 15m
    $287–574

  6. Shuttle to Lambert–St. Louis International Airport, fly to Rochester

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Rochester (RST)plane plane STL - RST
    8h 8m
    $218–636

  7. Fly Columbia Regional Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Columbia Regional Airport (COU) to Minneapolis–Saint Paul International Airport (MSP)plane plane COU - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 27m
    $219–609

  8. Shuttle to Lambert–St. Louis International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Minneapolis–Saint Paul International Airport (MSP)plane plane STL - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 23m
    $569–1,148

  9. Bus

    1. Take the bus from Jefferson City to Kansas City Bus Stationbus bus
    2. Take the bus from Kansas City Bus Station to Saint Paul Union Depotbus bus
    3. Take the bus from St. Paul to Rochesterbus bus
    15h 41m
    $159–245

Jefferson City to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration18h 17mAverage Duration
Ticket$204Cheapest Price
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Questions & Answers

Map of how to get from Jefferson City to Mayo Clinic.ExpandLaunch map view
  • Distance: 381.9 mi
  • Duration: 5h 37m

What companies run services between Jefferson City, MO, USA and Mayo Clinic, MN, USA?

United Airlines and American Airlines fly from Columbia Regional Airport (COU) to Rochester (RST) 3 times a day. Alternatively, you can take a vehicle from Jefferson City to Mayo Clinic via Jefferson City, Kansas City Bus Station, St. Paul, and Rochester in around 15h 41m.

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