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How to get fromJefferson City to Milwaukeeby plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, shuttle, or train

Find Transport to Milwaukee

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There are 7 ways to get from Jefferson City to Milwaukee by plane, train (Amtrak), bus (Greyhound, Flixbus), car, bus, shuttle, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Columbia Regional Airport to General Mitchell International Airport

    best
    1. Fly from Columbia Regional Airport (COU) to General Mitchell International Airport (MKE)plane plane COU - MKE
    4h 38m
    $160–570

  2. Drive  462.4 mi

    cheapest
    1. Drive from Jefferson City to Milwaukeecar car 462.4 mi
    8h 20m
    $85–122

  3. Train (Amtrak)

    1. Take the train from Jefferson City Station to Chicago Union Stationtrain train Lincoln Service Missouri River Runner
    2. Take the train from Chicago Union Station to Milwaukeetrain train Hiawatha Service / ...
    10h 40m
    $125–278

  4. Bus

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    13h 28m
    $93–152

  5. Fly Columbia Regional Airport to Chicago O'Hare International Airport, bus

    1. Fly from Columbia Regional Airport (COU) to Chicago O'Hare International Airport (ORD)plane plane COU - ORD
    2. Take the bus from Chicago to Milwaukee Intermodal Stationbus bus
    4h 27m
    $136–382

  6. Shuttle to Lambert–St. Louis International Airport, fly to General Mitchell International Airport

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane plane STL - MKE
    4h 46m
    $620–999

  7. Train, bus

    1. Take the train from Jefferson City Station to Summit Amtraktrain train Lincoln Service Missouri River Runner
    2. Take the bus from Multi-Modal/Rental Car Facility to Milwaukee Intermodal/Amtrak Stationbus bus Wisconsin Coach Lines
    11h 42m
    $140–267

Jefferson City to Milwaukee by train (Amtrak)

Calendar7Weekly Trains
Duration10h 40mAverage Duration
Ticket$125Cheapest Price
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Comparing Your Travel Options

Map of how to get from Jefferson City to Milwaukee.ExpandLaunch map view
  • Distance: 390.9 mi
  • Duration: 4h 38m

What companies run services between Jefferson City, MO, USA and Milwaukee, WI, USA?

American Airlines and United Airlines fly from Columbia Regional Airport (COU) to General Mitchell International Airport (MKE) every 4 hours. Alternatively, you can take a train from Jefferson City Station to Milwaukee via Chicago Union Station in around 10h 40m.

Airlines
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