Rome2Rio

How to get fromJefferson City to Tupeloby train, bus, car, plane, bus (Greyhound, Flixbus), or shuttle

Find Transport to Tupelo

See all options

There are 6 ways to get from Jefferson City to Tupelo by train, bus, car, plane, bus (Greyhound, Flixbus), or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Jefferson City Station to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Tupelobus bus
    11h 52m
    $134–218

  2. Drive  434.6 mi

    cheapest
    1. Drive from Jefferson City to Tupelocar car 434.6 mi
    8h 2m
    $80–115

  3. Drive to Waynesville-St. Robert Regional Airport, fly

    1. Drive from Jefferson City to Waynesville-St. Robert Regional Airport (TBN)car car
    2. Fly from Waynesville-St. Robert Regional Airport (TBN) to Tupelo Regional Airport (TUP)plane plane TBN - TUP
    8h 19m
    $218–839

  4. Bus

    1. Take the bus from Jefferson City to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    3. Take the bus from Memphis Bus Station to Tupelobus bus
    13h 3m
    $103–170

  5. Fly from Columbia Regional Airport

    1. Fly from Columbia Regional Airport (COU) to Tupelo Regional Airport (TUP)plane plane COU - TUP
    7h 36m
    $196–665

  6. Shuttle to Lambert–St. Louis International Airport, fly

    1. Take a shuttle bus from Jefferson City, Missouri to St Louis International Airportshuttle bus
    2. Fly from Lambert–St. Louis International Airport (STL) to Tupelo Regional Airport (TUP)plane plane STL - TUP
    7h 8m
    $231–664

Waynesville-St. Robert Regional Airport (TBN) to Tupelo Regional Airport (TUP) flights

Calendar3Weekly Planes
Duration6h 40mAverage Duration
Ticket$193Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Jefferson City to Tupelo.ExpandLaunch map view
  • Distance: 516.7 mi
  • Duration: 11h 52m

What companies run services between Jefferson City, MO, USA and Tupelo, MS, USA?

You can take a vehicle from Jefferson City to Tupelo via Jefferson City, St Louis Bus Station, Memphis Bus Station, and Tupelo in around 13h 3m. Alternatively, American Airlines, Corporate Flight Management Inc, and United Airlines fly from Columbia Regional Airport (COU) to Tupelo Regional Airport (TUP) once daily.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There