Rome2Rio

How to get fromJeffersonville to Chicagoby car, plane, bus (Amtrak), bus, train, or bus (Amtrak, Greyhound)

Find Transport to Chicago

See all options

There are 8 ways to get from Jeffersonville to Chicago by car, plane, bus (Amtrak), bus, train, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport

    best
    1. Drive from Jeffersonville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3h 50m
    $70–394

  2. Line 71 bus to Louisville International Airport, fly to Chicago O'Hare International Airport

    cheapest
    1. Take the bus from Court @ Meigs to W Jefferson @ S 5thbus bus
    2. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    4h 57m
    $50–301

  3. Bus (Amtrak)

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    7h 38m
    $52–63

  4. Bus, train via Speedway

    1. Take the bus from El Mercadito Grocery - Clarksville, IN to Indianapolisbus bus Memphis
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    9h 31m
    $123–299

  5. Drive 293.1 mi

    1. Drive from Jeffersonville to Chicagocar car 293.1 mi
    5h
    $54–78

  6. Line 71 bus to Louisville International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Court @ Meigs to W Jefferson @ S 5thbus bus
    2. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    4h 25m
    $55–351

  7. Bus via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus Greyhound US0100 / ...
    8h 25m
    $53–103

  8. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    9h 50m
    $84–178

Jeffersonville to Chicago by bus and foot (Amtrak)

Calendar14Weekly Services
Duration7h 38mAverage Duration
Ticket$52Cheapest Price
See schedules

Questions & Answers

Map of how to get from Jeffersonville to Chicago.ExpandLaunch map view
  • Distance: 413.4 mi
  • Duration: 3h 50m

What companies run services between Jeffersonville, IN, USA and Chicago, IL, USA?

Amtrak Thruway operates a bus from Louisville, KY to Chicago Union Station twice daily. Tickets cost $50–60 and the journey takes 6h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers