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How to get fromJeffersonville to Chicagoby car, plane, bus (Greyhound, Flixbus), bus, train, or bus (Amtrak)

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There are 7 ways to get from Jeffersonville to Chicago by car, plane, bus (Greyhound, Flixbus), bus, train, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport

    best
    1. Drive from Jeffersonville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3h 50m
    $55–294

  2. Bus

    cheapest
    1. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus Greyhound US0100
    7h 39m
    $42–93

  3. Bus, train

    1. Take the bus from El Mercadito Grocery - Clarksville, IN to Indianapolisbus bus Memphis
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    9h 31m
    $97–194

  4. Drive  293.1 mi

    1. Drive from Jeffersonville to Chicagocar car 293.1 mi
    5h
    $54–78

  5. Line 71 bus to Louisville International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Court @ Meigs to W Jefferson @ S 5thbus bus
    2. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    4h 25m
    $60–401

  6. Line 71 bus to Louisville International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Court @ Meigs to W Jefferson @ S 5thbus bus
    2. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    4h 57m
    $55–351

  7. Bus via Lafayette (Amtrak)

    1. Take the bus from Louisville, KY to Lafayette Amtrak Stationbus bus
    2. Take the bus from Lafayette Amtrak Station to Chicago Union Stationbus bus
    8h 37m
    $56–98

Jeffersonville to Chicago by bus and foot

Calendar40Weekly Services
Duration7h 39mAverage Duration
Ticket$42Cheapest Price
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Questions & Answers

Map of how to get from Jeffersonville to Chicago.ExpandLaunch map view
  • Distance: 413.4 mi
  • Duration: 3h 50m

What companies run services between Jeffersonville, IN, USA and Chicago, IL, USA?

Greyhound USA operates a bus from Louisville Bus Station to Chicago Bus Station 4 times a day. Tickets cost $45–90 and the journey takes 6h. Flixbus USA also services this route twice daily.

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