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How to get fromJeffersonville to Chicagoby car, plane, bus (Amtrak), bus, train, or bus (Amtrak, Greyhound)

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There are 10 ways to get from Jeffersonville to Chicago by car, plane, bus (Amtrak), bus, train, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Blue Grass Airport, fly to Chicago O'Hare International Airport

    best
    1. Drive from Jeffersonville to Lexington-Airport-LEXcar car
    2. Fly from Blue Grass Airport (LEX) to Chicago O'Hare International Airport (ORD)plane plane LEX - ORD
    3h 47m
    $50–274

  2. Bus (Amtrak)

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus Nashville
    7h 38m
    $52–63

  3. Bus, train via Speedway

    1. Take the bus from El Mercadito Grocery - Clarksville, IN to Indianapolisbus bus Memphis
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    9h 31m
    $147–244

  4. Drive  293.1 mi

    1. Drive from Jeffersonville to Chicagocar car 293.1 mi
    5h
    $54–78

  5. Drive to Covington, fly to Chicago O'Hare International Airport

    1. Drive from Jeffersonville to Covington (CVG)car car
    2. Fly from Covington (CVG) to Chicago O'Hare International Airport (ORD)plane plane CVG - ORD
    3h 55m
    $169–830

  6. Drive to Covington, fly to Chicago Midway International Airport

    1. Drive from Jeffersonville to Covington (CVG)car car
    2. Fly from Covington (CVG) to Chicago Midway International Airport (MDW)plane plane CVG - MDW
    3h 31m
    $169–390

  7. Line 71 bus to Louisville International Airport, fly to Chicago Midway International Airport

    1. Take the bus from Court @ Meigs to W Jefferson @ S 5thbus bus
    2. Fly from Louisville International Airport (SDF) to Chicago Midway International Airport (MDW)plane plane SDF - MDW
    4h 30m
    $65–411

  8. Line 71 bus to Louisville International Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Court @ Meigs to W Jefferson @ S 5thbus bus
    2. Fly from Louisville International Airport (SDF) to Chicago O'Hare International Airport (ORD)plane plane SDF - ORD
    4h 54m
    $50–341

  9. Bus via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus Nashville
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus Greyhound US0100 / ...
    8h 25m
    $54–98

  10. Bus, train (Amtrak)

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus Nashville
    2. Take the train from Indianapolis to Chicago Union Stationtrain train Cardinal
    9h 50m
    $124–218

Jeffersonville to Chicago by bus and foot (Amtrak)

Calendar14Weekly Services
Duration7h 38mAverage Duration
Ticket$52Cheapest Price
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Comparing Your Travel Options

Map of how to get from Jeffersonville to Chicago.ExpandLaunch map view
  • Distance: 413.4 mi
  • Duration: 3h 47m

What companies run services between Jeffersonville, IN, USA and Chicago, IL, USA?

Amtrak Thruway operates a bus from Louisville, KY to Chicago Union Station twice daily. Tickets cost $50–60 and the journey takes 6h.

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