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How to get fromKansas City to Mayo Clinicby bus, shuttle, car, or plane

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There are 4 ways to get from Kansas City to Mayo Clinic by bus, shuttle, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from Kansas City to Owatonnabus bus Jefferson Lines 802 / ...
    2. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus S MN Conn
    10h 40m
    $95–170

  2. Drive 401.4 mi

    cheapest
    1. Drive from Kansas City to Mayo Cliniccar car 401.4 mi
    6h 43m
    $74–106

  3. Fly to Rochester

    1. Fly from Kansas City (MCI) to Rochester (RST)plane plane MCI - RST
    6h 48m
    $81–510

  4. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Kansas City (MCI) to Minneapolis–Saint Paul International Airport (MSP)plane plane MCI - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 11m
    $652–1,002

Kansas City (MCI) to Rochester (RST) flights

Calendar49Weekly Planes
Duration4h 28mAverage Duration
Ticket$80Cheapest Price
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Questions & Answers

Map of how to get from Kansas City to Mayo Clinic.ExpandLaunch map view
  • Distance: 425 mi
  • Duration: 10h 40m

What companies run services between Kansas City, KS, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from Kansas City (MCI) to Rochester (RST) every 4 hours.

Airlines
Bus operators

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