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How to get fromKansas City to Cairoby bus, taxi, train, car, or plane

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There are 7 ways to get from Kansas City to Cairo by bus, taxi, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, taxi

    best
    1. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Cairotaxi taxi
    7h 57m
    $135–202

  2. Drive 379.3 mi

    cheapest
    1. Drive from Kansas City to Cairocar car 379.3 mi
    6h 41m
    $70–100

  3. Train, bus, taxi

    1. Take the train from Kansas City to St. Louistrain train
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Cairotaxi taxi
    9h 37m
    $188–314

  4. Fly to Barkley Regional Airport, taxi

    1. Fly from Kansas City (MCI) to Barkley Regional Airport (PAH)plane plane MCI - PAH
    2. Take the taxi from Barkley Regional Airport (PAH) to Cairotaxi taxi
    8h 10m
    $165–630

  5. Fly to Williamson County Regional Airport, taxi

    1. Fly from Kansas City (MCI) to Williamson County Regional Airport (MWA)plane plane MCI - MWA
    2. Take the taxi from Williamson County Regional Airport (MWA) to Cairotaxi taxi
    7h 25m
    $220–710

  6. Fly to Lambert–St. Louis International Airport, bus, taxi

    1. Fly from Kansas City (MCI) to Lambert–St. Louis International Airport (STL)plane plane MCI - STL
    2. Take the bus from St Louis Bus Station to Cape Girardeaubus bus
    3. Take the taxi from Cape Girardeau to Cairotaxi taxi
    7h 31m
    $185–733

  7. Fly to Nashville, bus, taxi

    1. Fly from Kansas City (MCI) to Nashville (BNA)plane plane MCI - BNA
    2. Take the bus from Nashville Bus Station to Paducah Bus Stationbus bus
    3. Take the taxi from Paducah Bus Station to Cairotaxi taxi
    8h 20m
    $509–1,252

Kansas City (MCI) to Barkley Regional Airport (PAH) flights

Calendar28Weekly Planes
Duration7h 55mAverage Duration
Ticket$107Cheapest Price
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Questions & Answers

Map of how to get from Kansas City to Cairo.ExpandLaunch map view
  • Distance: 395.7 mi
  • Duration: 7h 57m

What companies run services between Kansas City, MO, USA and Cairo, IL, USA?

There is no direct connection from Kansas City to Cairo. However, you can take the bus to St Louis Bus Station, take the bus to Cape Girardeau, then take the taxi to Cairo. Alternatively, you can take the train to St. Louis, walk to St Louis Bus Station, take the bus to Cape Girardeau, then take the taxi to Cairo.

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