Rome2Rio

How to get fromKansas City to Mayo Clinicby bus, shuttle, car, or plane

Find Transport to Mayo Clinic

See all options

There are 4 ways to get from Kansas City to Mayo Clinic by bus, shuttle, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from Kansas City to Owatonnabus bus Jefferson Lines 802 / ...
    2. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus S MN Conn
    9h 15m
    $96–165

  2. Drive 399 mi

    cheapest
    1. Drive from Kansas City to Mayo Cliniccar car 399 mi
    6h 39m
    $73–106

  3. Fly to Rochester

    1. Fly from Kansas City (MCI) to Rochester (RST)plane plane MCI - RST
    6h 43m
    $81–500

  4. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Kansas City (MCI) to Minneapolis–Saint Paul International Airport (MSP)plane plane MCI - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 15m
    $652–1,002

Kansas City (MCI) to Rochester (RST) flights

Calendar44Weekly Planes
Duration4h 27mAverage Duration
Ticket$81Cheapest Price
See schedules

Questions & Answers

Map of how to get from Kansas City to Mayo Clinic.ExpandLaunch map view
  • Distance: 421.1 mi
  • Duration: 9h 15m

What companies run services between Kansas City, MO, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from Kansas City (MCI) to Rochester (RST) every 4 hours.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides