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How to get fromKansas City to Murphysboroby bus (Greyhound, Amtrak, Flixbus), train, bus, car, or plane

Find Transport to Murphysboro

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There are 6 ways to get from Kansas City to Murphysboro by bus (Greyhound, Amtrak, Flixbus), train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    2. Take the bus from St. Louis to Carbondalebus bus Amtrak Thruway Connecting Service
    7h 10m
    $67–133

  2. Drive 332.9 mi

    cheapest
    1. Drive from Kansas City to Murphysborocar car 332.9 mi
    6h 3m
    $61–88

  3. Train, bus

    1. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    2. Take the bus from St. Louis to Carbondalebus bus Amtrak Thruway Connecting Service
    8h 50m
    $107–233

  4. Fly to Williamson County Regional Airport

    1. Fly from Kansas City (MCI) to Williamson County Regional Airport (MWA)plane plane MCI - MWA
    6h 34m
    $145–610

  5. Fly to Lambert–St. Louis International Airport, bus

    1. Fly from Kansas City (MCI) to Lambert–St. Louis International Airport (STL)plane plane MCI - STL
    2. Take the bus from St. Louis to Carbondalebus bus
    6h 44m
    $735–1,071

  6. Fly to Barkley Regional Airport, drive

    1. Fly from Kansas City (MCI) to Barkley Regional Airport (PAH)plane plane MCI - PAH
    2. Drive from Barkley Regional Airport (PAH) to Murphysborocar car
    8h 57m
    $113–571

Kansas City (MCI) to Williamson County Regional Airport (MWA) flights

Calendar35Weekly Planes
Duration5h 46mAverage Duration
Ticket$104Cheapest Price
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Questions & Answers

Map of how to get from Kansas City to Murphysboro.ExpandLaunch map view
  • Distance: 351.1 mi
  • Duration: 7h 10m

What companies run services between Kansas City, MO, USA and Murphysboro, IL, USA?

You can take a bus from Kansas City Bus Station to Murphysboro via St Louis Bus Station, St. Louis, and Carbondale in around 7h 10m. Alternatively, American Airlines and United Airlines fly from Kansas City (MCI) to Williamson County Regional Airport (MWA) 5 times a day.

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