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How to get fromKarlovy Vary to Mainzby train, bus, car, or plane

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There are 9 ways to get from Karlovy Vary to Mainz by train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Karlovy Vary to Chebtrain train Re / ...
    2. Take the train from Marktredwitz to Nürnberg Hbftrain train
    3. Take the train from Nürnberg Hbf to Mainz, Hauptbahnhoftrain train 91 / ...
    6h 52m
    €60–245

  2. Bus via Bayreuth

    cheapest
    1. Take the bus from Karlovy Vary to Bayreuth central train stationbus bus 068
    2. Take the bus from Bayreuth central train station to Mainz central train stationbus bus N1366
    8h 20m
    €35–55

  3. Bus

    1. Take the bus from Karlovy Vary to Frankfurt central train stationbus bus 068
    7h 48m
    €41–89

  4. Drive  381.8 km

    1. Drive from Karlovy Vary to Mainzcar car 381.8 km
    4h 5m
    €61–88

  5. Bus to Václav Havel Airport Prague, fly

    1. Take the bus from Karlovy Vary Terminal Bus Station to Prague Airport Terminal 1/2bus bus
    2. Fly from Václav Havel Airport Prague (PRG) to Frankfurt (FRA)plane plane PRG - FRA
    5h 4m
    €67–151

  6. Train via Frankfurt am Main

    1. Take the train from Karlovy Vary to Chebtrain train Re / ...
    2. Take the train from Marktredwitz to Nürnberg Hbftrain train
    3. Take the train from Nürnberg Hbf to Frankfurttrain train 41 / ...
    6h 57m
    €63–275

  7. Train, train to Nuremberg Airport, fly

    1. Take the train from Karlovy Vary to Chebtrain train
    2. Take the train from Marktredwitz to Nürnberg Hbftrain train
    3. Fly from Nuremberg Airport (NUE) to Frankfurt (FRA)plane plane NUE - FRA
    5h 49m
    €117–340

  8. Train, train to Dresden Airport, fly

    1. Take the train from Karlovy Vary to Usti Nad Labem Hlavni Nadrazitrain train
    2. Take the train from Usti Nad Labem Hlavni Nadrazi to Dresden Hbftrain train
    3. Fly from Dresden Airport (DRS) to Frankfurt (FRA)plane plane DRS - FRA
    7h 12m
    €152–365

  9. Train, train to Leipzig-Halle Airport, fly

    1. Take the train from Karlovy Vary to Johanngeorgenstadttrain train
    2. Take the train from Johanngeorgenstadt, Bahnhof to Zwickau, Hauptbahnhoftrain train
    3. Take the train from Zwickau, Hauptbahnhof to Leipzig/Halle Flughafentrain train
    4. Fly from Leipzig-Halle Airport (LEJ) to Frankfurt (FRA)plane plane LEJ - FRA
    7h 38m
    €136–344

Karlovy Vary to Mainz by train

Calendar70Weekly Trains
Duration6h 52mAverage Duration
Ticket€60Cheapest Price
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Comparing Your Travel Options

Map of how to get from Karlovy Vary to Mainz.ExpandLaunch map view
  • Distance: 462.2 km
  • Duration: 6h 52m

What companies run services between Karlovy Vary, Czechia and Mainz, Germany?

You can take a train from Karlovy Vary to Mainz, Hauptbahnhof via Cheb, Marktredwitz, and Nürnberg Hbf in around 6h 52m. Alternatively, FlixBus operates a bus from Karlovy Vary to Frankfurt central train station 5 times a week. Tickets cost €30–50 and the journey takes 6h 55m.

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