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How to get fromKarlovy Vary to Mainzby train, bus, car, or plane

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There are 7 ways to get from Karlovy Vary to Mainz by train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Karlovy Vary to Chebtrain train Re / ...
    2. Take the train from Cheb to Nuernberg Hbftrain train
    3. Take the train from Nuernberg Hbf to Mainz Hbftrain train Ice / ...
    7h 4m
    €59–121

  2. Bus

    cheapest
    1. Take the bus from Karlovy Vary to Frankfurt central train stationbus bus 068
    7h 48m
    €39–66

  3. Drive  381.8 km

    1. Drive from Karlovy Vary to Mainzcar car 381.8 km
    4h 5m
    €72–103

  4. Bus to Václav Havel Airport Prague, fly

    1. Take the bus from Karlovy Vary Terminal Bus Station to Prague Airport Terminal 1/2bus bus
    2. Fly from Václav Havel Airport Prague (PRG) to Frankfurt (FRA)plane plane PRG - FRA
    5h 9m
    €66–148

  5. Train, train to Nuremberg Airport, fly

    1. Take the train from Karlovy Vary to Chebtrain train
    2. Take the train from Cheb to Nuernberg Hbftrain train
    3. Fly from Nuremberg Airport (NUE) to Frankfurt (FRA)plane plane NUE - FRA
    6h 4m
    €119–208

  6. Train, train to Leipzig-Halle Airport, fly

    1. Take the train from Karlovy Vary to Johanngeorgenstadttrain train
    2. Take the train from Johanngeorgenstadt, Bahnhof to Zwickau, Hauptbahnhoftrain train
    3. Take the train from Zwickau, Hauptbahnhof to Leipzig/Halle Flughafentrain train
    4. Fly from Leipzig-Halle Airport (LEJ) to Frankfurt (FRA)plane plane LEJ - FRA
    7h 38m
    €119–214

  7. Train, train to Dresden Airport, fly

    1. Take the train from Karlovy Vary to Usti Nad Labem Hlavni Nadrazitrain train
    2. Take the train from Usti Nad Labem Hlavni Nadrazi to Dresden Hbftrain train
    3. Fly from Dresden Airport (DRS) to Frankfurt (FRA)plane plane DRS - FRA
    7h 27m
    €140–345

Karlovy Vary to Mainz by train

Calendar95Weekly Trains
Duration7h 4mAverage Duration
Ticket€59Cheapest Price
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Comparing Your Travel Options

Map of how to get from Karlovy Vary to Mainz.ExpandLaunch map view
  • Distance: 462 km
  • Duration: 7h 4m

What companies run services between Karlovy Vary, Czechia and Mainz, Germany?

You can take a train from Karlovy Vary to Mainz Hbf via Cheb and Nuernberg Hbf in around 7h 4m. Alternatively, FlixBus operates a bus from Karlovy Vary to Frankfurt central train station once daily. Tickets cost €35–55 and the journey takes 6h 55m.

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