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How to get fromKarlsruhe to Domodossolaby train, bus, car, or plane

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There are 10 ways to get from Karlsruhe to Domodossola by train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Domodossolatrain train Ec
    5h 29m
    €107–422

  2. Train via Spiez

    cheapest
    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Spieztrain train Ic6 / ...
    3. Take the train from Spiez to Domodossolatrain train Ec / ...
    5h 51m
    €51–336

  3. Bus

    1. Take the bus from Karlsruhe central train station to Milanbus bus FlixBus N474
    2. Take the bus from Aeroporto Malpensa - Terminal 1 to Domodossola - Stazione Ferroviariabus bus 3
    10h 50m
    €59–92

  4. Drive 495.4 km

    1. Drive from Karlsruhe to Domodossolacar car 495.4 km
    5h 15m
    €78–112

  5. Train to Stuttgart Airport, fly to Zurich Airport, train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Zurich Airport (ZRH)plane plane STR - ZRH
    3. Take the train from Zürich HB to Domodossolatrain train
    6h 41m
    €211–630

  6. Train via Zurich

    1. Take the train from Karlsruhe Hbf to Zürich HBtrain train
    2. Take the train from Zürich HB to Locarnotrain train
    3. Take the train from Locarno FART to Domodossolatrain train 72 / ...
    10h 33m
    €102–169

  7. Train to Frankfurt, fly to Milano Malpensa Airport, bus

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Milano Malpensa Airport (MXP)plane plane FRA - MXP
    3. Take the bus from Aeroporto Malpensa - Terminal 1 to Domodossola - Stazione Ferroviariabus bus
    6h 29m
    €88–292

  8. Train to Stuttgart Airport, fly to Milano Malpensa Airport, bus

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Milano Malpensa Airport (MXP)plane plane STR - MXP
    3. Take the bus from Aeroporto Malpensa - Terminal 1 to Domodossola - Stazione Ferroviariabus bus
    6h 33m
    €92–238

  9. Train to Frankfurt, fly to Basel, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Basel (BSL)plane plane FRA - BSL
    3. Take the train from Basel SBB to Domodossolatrain train
    7h 9m
    €222–658

  10. Train to Frankfurt, fly to Milan Linate Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Milan Linate Airport (LIN)plane plane FRA - LIN
    3. Take the train from Milano Centrale to Domodossolatrain train
    7h 16m
    €96–322

Karlsruhe to Domodossola by train

Calendar15Weekly Trains
Duration5h 29mAverage Duration
Ticket€107Cheapest Price
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Questions & Answers

Map of how to get from Karlsruhe to Domodossola.ExpandLaunch map view
  • Distance: 434.7 km
  • Duration: 5h 29m

What companies run services between Karlsruhe, Germany and Domodossola, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Domodossola via Basel SBB in around 5h 29m. Alternatively, you can take a bus from Karlsruhe central train station to Domodossola - Stazione Ferroviaria via Milan and Aeroporto Malpensa - Terminal 1 in around 10h 50m.

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