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How to get fromKarlsruhe to Genoaby train (Trenitalia), bus, car, train, plane, or night train

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There are 11 ways to get from Karlsruhe to Genoa by train (Trenitalia), bus, car, train, plane, or night train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Genova Brignoletrain train Ic
    9h 49m
    €82–304

  2. Bus

    cheapest
    1. Take the bus from Karlsruhe central train station to Genoabus bus FlixBus N177
    10h 30m
    €60–95

  3. Drive  668.1 km

    1. Drive from Karlsruhe to Genoacar car 668.1 km
    6h 40m
    €125–180

  4. Train to Stuttgart Airport, fly to Genoa Cristoforo Colombo Airport

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Genoa Cristoforo Colombo Airport (GOA)plane plane STR - GOA
    7h 22m
    €112–311

  5. Night train, train

    1. Take the nighttrain from Karlsruhe Hbf to Zuerich Hbnighttrain night train Nj
    2. Take the train from Zürich HB to Luganotrain train Ec / ...
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Genova Brignoletrain train Ic
    10h 28m
    €120–263

  6. Train, bus

    1. Take the train from Karlsruhe Hbf to Zuerich Hbtrain train Ec
    2. Take the bus from Zurich Central Bus Station Sihlquai to Como Piazzale San Gottardobus bus
    3. Take the train from Como S.Giovanni to Genova Brignoletrain train
    13h 40m
    €100–115

  7. Train to Strasbourg International Airport, fly to Nice Côte D'Azur International Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain train
    2. Fly from Strasbourg International Airport (SXB) to Nice Côte D'Azur International Airport (NCE)plane plane SXB - NCE
    3. Take the train from Saint-Laurent-du-Var to Ventimigliatrain train
    4. Take the train from Ventimiglia to Genova P.Za Principetrain train
    7h 12m
    €74–282

  8. Train to Frankfurt, fly to Milan Linate Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Milan Linate Airport (LIN)plane plane FRA - LIN
    3. Take the train from Milano Forlanini to Genova P.Za Principetrain train
    7h 10m
    €73–215

  9. Train to Stuttgart Airport, fly to Milan Linate Airport, train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Milan Linate Airport (LIN)plane plane STR - LIN
    3. Take the train from Milano Forlanini to Genova P.Za Principetrain train
    7h 10m
    €128–333

  10. Train to Frankfurt, fly to Turin Caselle Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Turin Caselle Airport (TRN)plane plane FRA - TRN
    3. Take the train from Torino Lingotto to Genova Brignoletrain train
    7h 50m
    €135–365

  11. Train to Frankfurt, fly to Milano Malpensa Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Milano Malpensa Airport (MXP)plane plane FRA - MXP
    3. Take the train from Malpensa Aeroporto T1 to Milano Centraletrain train
    4. Take the train from Milano Centrale to Genova Brignoletrain train
    7h 47m
    €100–262

Karlsruhe to Genoa by train

Calendar76Weekly Trains
Duration9h 49mAverage Duration
Ticket€82Cheapest Price
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Comparing Your Travel Options

Map of how to get from Karlsruhe to Genoa.ExpandLaunch map view
  • Distance: 663.5 km
  • Duration: 9h 49m

What companies run services between Karlsruhe, Germany and Genoa, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Genova Brignole via Basel SBB, Lugano, and Milano Centrale in around 9h 49m. Alternatively, FlixBus operates a bus from Karlsruhe central train station to Genoa once daily. Tickets cost €60–95 and the journey takes 10h 30m.

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