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How to get fromKarlsruhe to Ispraby train, bus, night train, car, or plane

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There are 10 ways to get from Karlsruhe to Ispra by train, bus, night train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ic21 / ...
    8h 30m
    €48–250

  2. Bus

    1. Take the bus from Karlsruhe central train station to Como Grandatebus bus FlixBus 024
    12h 43m
    €54–81

  3. Night train, train

    1. Take the nighttrain from Karlsruhe Hbf to Zuerich Hbnighttrain night train Nj
    2. Take the train from Zürich HB to Luganotrain train Ec / ...
    9h 9m
    €86–206

  4. Drive  490.8 km

    1. Drive from Karlsruhe to Ispracar car 490.8 km
    5h 11m
    €91–132

  5. Train via Freiburg im Breisgau

    1. Take the train from Karlsruhe Hauptbahnhof to Freiburg im Breisgau Train Stationtrain train 12 / ...
    2. Take the train from Freiburg im Breisgau Train Station to Luganotrain train Ec
    9h 20m
    €122–260

  6. Train via Zurich

    1. Take the train from Karlsruhe Hbf to Zuerich Hbtrain train Ec
    2. Take the train from Zürich HB to Castione-Arbedotrain train
    3. Take the train from Castione to Varesetrain train S50
    11h 8m
    €135–169

  7. Train to Frankfurt, fly to Milano Malpensa Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Milano Malpensa Airport (MXP)plane plane FRA - MXP
    3. Take the train from Malpensa Aeroporto T1 to Varesetrain train
    6h 49m
    €88–247

  8. Train to Frankfurt, fly to Milan Linate Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Milan Linate Airport (LIN)plane plane FRA - LIN
    3. Take the train from Milano Cadorna to Gaviratetrain train
    7h 19m
    €60–206

  9. Train to Stuttgart Airport, fly to Milan Linate Airport, train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Milan Linate Airport (LIN)plane plane STR - LIN
    3. Take the train from Milano Cadorna to Gaviratetrain train
    7h 19m
    €120–324

  10. Train, train to Zurich Airport, fly to Milano Malpensa Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Milano Malpensa Airport (MXP)plane plane ZRH - MXP
    4. Take the train from Malpensa Aeroporto T1 to Varesetrain train
    7h 46m
    €131–367

Karlsruhe to Ispra by train and bus

Calendar76Weekly Services
Duration8h 30mAverage Duration
Ticket€48Cheapest Price
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Comparing Your Travel Options

Map of how to get from Karlsruhe to Ispra.ExpandLaunch map view
  • Distance: 507.7 km
  • Duration: 8h 30m

What companies run services between Karlsruhe, Germany and Ispra, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Ispra, Mazzini 59,banca via Basel SBB, Lugano, Varese, and Varese, V. Veneto 9 in around 8h 30m. Alternatively, FlixBus operates a bus from Karlsruhe central train station to Como Grandate 5 times a week. Tickets cost €45–75 and the journey takes 9h 20m.

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