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How to get fromKarlsruhe to Ispraby train, bus, night train, car, or plane

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There are 9 ways to get from Karlsruhe to Ispra by train, bus, night train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Bellinzonatrain train Ec
    3. Take the train from Bellinzona to Varesetrain train S50
    8h 17m
    €47–183

  2. Bus

    1. Take the bus from Karlsruhe central train station to Como Grandatebus bus FlixBus 024
    12h 44m
    €50–76

  3. Night train, train

    1. Take the nighttrain from Karlsruhe Hbf to Zuerich Hbnighttrain night train Nj
    2. Take the train from Zürich HB to Bellinzonatrain train Ec / ...
    3. Take the train from Bellinzona to Varesetrain train S50
    9h 10m
    €78–180

  4. Drive  490.8 km

    1. Drive from Karlsruhe to Ispracar car 490.8 km
    5h 11m
    €80–115

  5. Train to Stuttgart Airport, fly to Milano Malpensa Airport, train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Milano Malpensa Airport (MXP)plane plane STR - MXP
    3. Take the train from Malpensa Aeroporto T1 to Varesetrain train
    6h 48m
    €88–285

  6. Train, train to Frankfurt, fly to Milano Malpensa Airport, bus

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Milano Malpensa Airport (MXP)plane plane FRA - MXP
    4. Take the train from Malpensa Aeroporto T1 to Varesetrain train
    5. Take the bus from Varese, V. Veneto 9 to Ispra, Mazzini 59,bancabus bus
    6h 40m
    €79–264

  7. Train to Stuttgart Airport, fly to Milan Linate Airport, train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Milan Linate Airport (LIN)plane plane STR - LIN
    3. Take the train from Milano Cadorna to Gaviratetrain train
    7h 28m
    €135–377

  8. Train, train to Zurich Airport, fly to Milano Malpensa Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Milano Malpensa Airport (MXP)plane plane ZRH - MXP
    4. Take the train from Malpensa Aeroporto T1 to Varesetrain train
    7h 46m
    €127–343

  9. Train, train to Frankfurt, fly to Milan Linate Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Milan Linate Airport (LIN)plane plane FRA - LIN
    4. Take the train from Milano Cadorna to Gaviratetrain train
    7h 25m
    €61–236

Karlsruhe to Ispra by train and bus

Calendar117Weekly Services
Duration8h 17mAverage Duration
Ticket€47Cheapest Price
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Comparing Your Travel Options

Map of how to get from Karlsruhe to Ispra.ExpandLaunch map view
  • Distance: 507.7 km
  • Duration: 8h 17m

What companies run services between Karlsruhe, Germany and Ispra, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Ispra, Mazzini 59,banca via Basel SBB, Bellinzona, Varese, and Varese, V. Veneto 9 in around 8h 17m. Alternatively, FlixBus operates a bus from Karlsruhe central train station to Como Grandate 5 times a week. Tickets cost €45–70 and the journey takes 9h 20m.

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