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How to get fromKarlsruhe to Palermoby train, plane, train (Trenitalia), car, car ferry, or bus

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There are 11 ways to get from Karlsruhe to Palermo by train, plane, train (Trenitalia), car, car ferry, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Stuttgart Airport, fly to Palermo Airport

    best
    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Palermo Airport (PMO)plane plane STR - PMO
    6h 21m
    €95–284

  2. Train to Basel, fly to Palermo Airport

    cheapest
    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Fly from Basel (BSL) to Palermo Airport (PMO)plane plane BSL - PMO
    7h 4m
    €75–308

  3. Train

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Roma Terminitrain train
    5. Take the train from Roma Termini to Palermo Centraletrain train Ic
    23h 32m
    €228–666

  4. Drive, car ferry

    1. Drive from Karlsruhe to Port of Genoacar car
    2. Take the carferry from Port of Genoa to Port of Palermocarferry car ferry
    27h 25m
    €206–303

  5. Bus via Milan

    1. Take the bus from Karlsruhe central train station to Milano, Autostazione Lampugnanobus bus N77
    2. Take the bus from Milano, Autostazione Lampugnano to Palermobus bus N597
    31h 50m
    €168–286

  6. Train, train to Frankfurt, fly to Palermo Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane plane FRA - PMO
    6h 27m
    €96–271

  7. Train, train to Zurich Airport, fly to Palermo Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Palermo Airport (PMO)plane plane ZRH - PMO
    8h 14m
    €132–381

  8. Line 85569 train to Karlsruhe/Baden-Baden Airport, fly to Palermo Airport

    1. Take the train from Karlsruhe Marktplatz to Rastatttrain train
    2. Fly from Karlsruhe/Baden-Baden Airport (FKB) to Palermo Airport (PMO)plane plane FKB - PMO
    6h 14m

  9. Train to Stuttgart Airport, fly to Catania–Fontanarossa Airport, bus

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Catania–Fontanarossa Airport (CTA)plane plane STR - CTA
    3. Take the bus from Catania Fontanarossa Airport Bus Stop to Palermo Via Tommaso Fazellobus bus
    9h 8m
    €98–295

  10. Train via Zurich

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Zürich HBtrain train Tgv / ...
    3. Take the train from Zürich HB to Como S. Giovannitrain train Ec
    4. Take the train from Como S.Giovanni to Rhotrain train S11
    5. Take the train from RHO Fiera to Roma Terminitrain train
    6. Take the train from Roma Termini to Palermo Centraletrain train Ic
    26h 41m
    €286–691

  11. Bus

    1. Take the bus from Karlsruhe Central Bus Station to Palermo Piazza Cairolibus bus
    33h 7m
    €260–370

Karlsruhe to Palermo by train

Calendar26Weekly Trains
Duration23h 32mAverage Duration
Ticket€228Cheapest Price
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Questions & Answers

Map of how to get from Karlsruhe to Palermo.ExpandLaunch map view
  • Distance: 1,337.4 km
  • Duration: 6h 21m

What companies run services between Karlsruhe, Germany and Palermo, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Palermo Centrale via Basel SBB, Lugano, Milano Centrale, and Roma Termini in around 23h 32m. Alternatively, you can take a bus from Karlsruhe central train station to Palermo via Milano, Autostazione Lampugnano in around 31h 50m.

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