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How to get fromKarlsruhe to Palermoby train, plane, train (Trenitalia), car, car ferry, or bus

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There are 9 ways to get from Karlsruhe to Palermo by train, plane, train (Trenitalia), car, car ferry, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Stuttgart Airport, fly

    best
    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Palermo Airport (PMO)plane plane STR - PMO
    6h 14m
    €93–294

  2. Train, train to Allgäu Airport, Memmingen, fly

    cheapest
    1. Take the train from Karlsruhe Hauptbahnhof to Ulm Hauptbahnhoftrain train
    2. Take the train from Ulm Hauptbahnhof to Memmingen, Bahnhof ZOBtrain train
    3. Fly from Allgäu Airport, Memmingen (FMM) to Palermo Airport (PMO)plane plane FMM - PMO
    7h 58m
    €79–312

  3. Train

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Roma Terminitrain train
    5. Take the train from Roma Termini to Palermo Centraletrain train Ic
    23h 32m
    €236–549

  4. Drive, car ferry

    1. Drive from Karlsruhe to Port of Genoacar car
    2. Take the carferry from Port of Genoa to Port of Palermocarferry car ferry
    26h 10m
    €220–323

  5. Bus via Milan

    1. Take the bus from Karlsruhe central train station to Milano, Autostazione Lampugnanobus bus N77
    2. Take the bus from Milano, Autostazione Lampugnano to Palermobus bus N597
    31h 50m
    €192–287

  6. Train to Frankfurt, fly

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Palermo Airport (PMO)plane plane FRA - PMO
    6h 23m
    €99–264

  7. Train to Basel, fly

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Fly from Basel (BSL) to Palermo Airport (PMO)plane plane BSL - PMO
    7h 5m
    €85–325

  8. Train, bus

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Domodossolatrain train Ec
    3. Take the bus from Domodossola to Rho Fiera Milanobus bus Re4
    4. Take the train from Milano Rogoredo to Roma Terminitrain train
    5. Take the train from Roma Termini to Palermo Centraletrain train Ic
    24h 16m

  9. Bus

    1. Take the bus from Karlsruhe Central Bus Station to Palermo Piazza Cairolibus bus
    32h 59m
    €260–370

Karlsruhe to Palermo by bus

Calendar7Weekly Buses
Duration31h 50mAverage Duration
Ticket€192Cheapest Price
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Comparing Your Travel Options

Map of how to get from Karlsruhe to Palermo.ExpandLaunch map view
  • Distance: 1,337.4 km
  • Duration: 6h 14m

What companies run services between Karlsruhe, Germany and Palermo, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Palermo Centrale via Basel SBB, Lugano, Milano Centrale, and Roma Termini in around 23h 32m. Alternatively, you can take a bus from Karlsruhe central train station to Palermo via Milano, Autostazione Lampugnano in around 31h 50m.

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