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How to get fromKarlsruhe to Pisaby train, plane, train (Trenitalia), bus, car, or night train

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There are 10 ways to get from Karlsruhe to Pisa by train, plane, train (Trenitalia), bus, car, or night train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Frankfurt, fly to Florence Peretola Airport, train

    best
    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    3. Take the train from Firenze S.M.N. to Pisa Centraletrain train
    6h 34m
    €152–374

  2. Train to Strasbourg International Airport, fly to Florence Peretola Airport, train

    cheapest
    1. Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain train
    2. Fly from Strasbourg International Airport (SXB) to Florence Peretola Airport (FLR)plane plane SXB - FLR
    3. Take the train from Firenze S.M.N. to Pisa Centraletrain train
    6h 15m
    €80–352

  3. Train

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Pisa Centraletrain train Re
    11h 28m
    €115–352

  4. Bus

    1. Take the bus from Karlsruhe Central Bus Station to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Pisabus bus 443 / ...
    13h 50m
    €122–168

  5. Drive  808.1 km

    1. Drive from Karlsruhe to Pisacar car 808.1 km
    8h 3m
    €146–210

  6. Train to Frankfurt, fly to Bologna Guglielmo Marconi Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Pisa Centraletrain train
    7h 2m
    €135–333

  7. Train to Frankfurt, fly to Pisa International Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Pisa International Airport (PSA)plane plane FRA - PSA
    4h 44m
    €121–319

  8. Train, train to Zurich Airport, fly to Florence Peretola Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    4. Take the train from Firenze S.M.N. to Pisa Centraletrain train
    8h 27m
    €169–478

  9. Night train, train

    1. Take the nighttrain from Karlsruhe Hbf to Zuerich Hbnighttrain night train Nj
    2. Take the train from Zürich HB to Luganotrain train Ec / ...
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Pisa Centraletrain train Ic
    13h 26m
    €135–293

  10. Bus via Milan Bergamo Airport (BGY)

    1. Take the bus from Karlsruhe central train station to Bergamobus bus FlixBus 024
    2. Take the bus from Bergamo to Pisabus bus N1508
    19h 45m
    €97–149

Karlsruhe to Pisa by train

Calendar76Weekly Trains
Duration11h 28mAverage Duration
Ticket€115Cheapest Price
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Comparing Your Travel Options

Map of how to get from Karlsruhe to Pisa.ExpandLaunch map view
  • Distance: 937.7 km
  • Duration: 6h 34m

What companies run services between Karlsruhe, Germany and Pisa, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Pisa Centrale via Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 11h 28m. Alternatively, you can take a bus from Karlsruhe Central Bus Station to Pisa via Florence Villa Constanza Bus Station in around 13h 50m.

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