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How to get fromKarlsruhe to Sienaby train (Trenitalia), bus, train, night train, car, or plane

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There are 12 ways to get from Karlsruhe to Siena by train (Trenitalia), bus, train, night train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    11h 51m
    €110–586

  2. Bus via Karlsruhe central train station

    cheapest
    1. Take the bus from Karlsruhe central train station to Florence Villa Constanza Bus Stationbus bus N77
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    16h 5m
    €73–117

  3. Bus

    1. Take the bus from Karlsruhe Central Bus Station to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    13h 7m
    €119–162

  4. Train, night train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train Re
    2. Take the nighttrain from Stuttgart Hbf to Verona Porta Nuovanighttrain night train Nj
    3. Take the train from Verona Porta Nuova to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    18h 50m
    €99–265

  5. Drive  889.8 km

    1. Drive from Karlsruhe to Sienacar car 889.8 km
    8h 46m
    €141–203

  6. Train to Stuttgart Airport, fly to Florence Peretola Airport, train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Florence Peretola Airport (FLR)plane plane STR - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 49m
    €131–364

  7. Train, train to Frankfurt, fly to Florence Peretola Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    7h 12m
    €152–388

  8. Train, train to Frankfurt, fly to Pisa International Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Pisa International Airport (PSA)plane plane FRA - PSA
    4. Take the train from Pisa Centrale to Empolitrain train
    5. Take the train from Empoli to Sienatrain train
    7h 5m
    €136–367

  9. Train, train to Frankfurt, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    4. Take the train from Bologna Centrale to Firenze S.M.N.train train
    5. Take the train from Firenze S.M.N. to Sienatrain train
    7h 37m
    €135–383

  10. Train, train to Zurich Airport, fly to Florence Peretola Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    8h 54m
    €168–519

  11. Train, train to Frankfurt, fly to Venice Marco Polo Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Venice Marco Polo Airport (VCE)plane plane FRA - VCE
    4. Take the train from Venezia Mestre to Firenze S.M.N.train train
    5. Take the train from Firenze S.M.N. to Sienatrain train
    9h 18m
    €131–388

  12. Train, train to Zurich Airport, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Bologna Guglielmo Marconi Airport (BLQ)plane plane ZRH - BLQ
    4. Take the train from Bologna Centrale to Firenze S.M.N.train train
    5. Take the train from Firenze S.M.N. to Sienatrain train
    9h 24m
    €161–554

Karlsruhe to Siena by train

Calendar76Weekly Trains
Duration11h 51mAverage Duration
Ticket€110Cheapest Price
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Questions & Answers

Map of how to get from Karlsruhe to Siena.ExpandLaunch map view
  • Distance: 919.5 km
  • Duration: 11h 51m

What companies run services between Karlsruhe, Germany and Siena, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Siena via Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 11h 51m. Alternatively, you can take a bus from Karlsruhe Central Bus Station to Siena via Florence Villa Constanza Bus Station in around 13h 7m.

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