Rome2Rio

How to get fromKarlsruhe to Sienaby train (Trenitalia), bus, car, train, or plane

Find Transport to Siena

See all options

There are 11 ways to get from Karlsruhe to Siena by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    11h 52m
    €105–317

  2. Bus via Karlsruhe central train station

    cheapest
    1. Take the bus from Karlsruhe central train station to Florence Villa Constanza Bus Stationbus bus N77
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    16h 5m
    €81–122

  3. Bus

    1. Take the bus from Karlsruhe Central Bus Station to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    13h 5m
    €119–163

  4. Drive  889.8 km

    1. Drive from Karlsruhe to Sienacar car 889.8 km
    8h 46m
    €144–208

  5. Train to Stuttgart Airport, fly to Florence Peretola Airport, train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Florence Peretola Airport (FLR)plane plane STR - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 41m
    €129–370

  6. Train, train to Frankfurt, fly to Florence Peretola Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    7h 8m
    €150–369

  7. Train to Strasbourg International Airport, fly to Florence Peretola Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain train
    2. Fly from Strasbourg International Airport (SXB) to Florence Peretola Airport (FLR)plane plane SXB - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 43m
    €89–371

  8. Train, train to Frankfurt, fly to Pisa International Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Pisa International Airport (PSA)plane plane FRA - PSA
    4. Take the train from Pisa Centrale to Empolitrain train
    5. Take the train from Empoli to Sienatrain train
    7h 5m
    €134–357

  9. Train, train to Frankfurt, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Mannheim, Hauptbahnhoftrain train
    2. Take the train from Mannheim, Hauptbahnhof to Frankfurttrain train
    3. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    4. Take the train from Bologna Centrale to Firenze S.M.N.train train
    5. Take the train from Firenze S.M.N. to Sienatrain train
    7h 41m
    €132–369

  10. Train, train to Zurich Airport, fly to Florence Peretola Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    8h 54m
    €163–418

  11. Train, train to Zurich Airport, fly to Bologna Guglielmo Marconi Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Bologna Guglielmo Marconi Airport (BLQ)plane plane ZRH - BLQ
    4. Take the train from Bologna Centrale to Firenze S.M.N.train train
    5. Take the train from Firenze S.M.N. to Sienatrain train
    9h 27m
    €155–458

Karlsruhe to Siena by train

Calendar76Weekly Trains
Duration11h 52mAverage Duration
Ticket€105Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Karlsruhe to Siena.ExpandLaunch map view
  • Distance: 919.5 km
  • Duration: 11h 52m

What companies run services between Karlsruhe, Germany and Siena, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Siena via Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 11h 52m. Alternatively, you can take a bus from Karlsruhe Central Bus Station to Siena via Florence Villa Constanza Bus Station in around 13h 5m.

Airlines
Train operators
Bus operators

Want to know more about travelling around Italy

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Italy Travel Guides

Read the travel guideItaly Travel Guides

Booking & Getting There