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How to get fromKarlsruhe to Sienaby train, plane, train (Trenitalia), bus, car, or night train

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There are 11 ways to get from Karlsruhe to Siena by train, plane, train (Trenitalia), bus, car, or night train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Frankfurt, fly to Florence Peretola Airport, train

    best
    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    7h 2m
    €155–379

  2. Train to Strasbourg International Airport, fly to Florence Peretola Airport, train

    cheapest
    1. Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain train
    2. Fly from Strasbourg International Airport (SXB) to Florence Peretola Airport (FLR)plane plane SXB - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    6h 43m
    €83–357

  3. Train

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    11h 55m
    €108–355

  4. Bus

    1. Take the bus from Karlsruhe Central Bus Station to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    13h 5m
    €120–164

  5. Drive  889.8 km

    1. Drive from Karlsruhe to Sienacar car 889.8 km
    8h 46m
    €165–238

  6. Train to Stuttgart Airport, fly to Florence Peretola Airport, train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Florence Peretola Airport (FLR)plane plane STR - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 27m
    €134–357

  7. Train to Frankfurt, fly to Bologna Guglielmo Marconi Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    7h 29m
    €138–338

  8. Train, train to Zurich Airport, fly to Florence Peretola Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    8h 54m
    €162–481

  9. Train to Frankfurt, fly to Venice Marco Polo Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Venice Marco Polo Airport (VCE)plane plane FRA - VCE
    3. Take the train from Venezia Mestre to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    9h 16m
    €150–349

  10. Night train, train

    1. Take the nighttrain from Karlsruhe Hbf to Zuerich Hbnighttrain night train Nj
    2. Take the train from Zürich HB to Luganotrain train Ec / ...
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the train from Firenze S.M.N. to Sienatrain train Re
    12h 34m
    €146–314

  11. Bus via Karlsruhe central train station

    1. Take the bus from Karlsruhe central train station to Florence Villa Constanza Bus Stationbus bus N77
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus N528 / ...
    16h 5m
    €87–128

Karlsruhe to Siena by train

Calendar76Weekly Trains
Duration11h 55mAverage Duration
Ticket€108Cheapest Price
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Comparing Your Travel Options

Map of how to get from Karlsruhe to Siena.ExpandLaunch map view
  • Distance: 952.8 km
  • Duration: 7h 2m

What companies run services between Karlsruhe, Germany and Siena, Italy?

You can take a train from Karlsruhe Hauptbahnhof to Siena via Basel SBB, Lugano, Milano Centrale, and Firenze S.M.N. in around 11h 55m. Alternatively, you can take a bus from Karlsruhe Central Bus Station to Siena via Florence Villa Constanza Bus Station in around 13h 5m.

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