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How to get fromKarlsruhe to Sienaby train, bus, car, or plane

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There are 9 ways to get from Karlsruhe to Siena by train, bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train, bus

    best
    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train 12 / ...
    2. Take the train from Basel SBB to Luganotrain train Ec
    3. Take the train from Lugano to Milano Centraletrain train
    4. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    5. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    11h 54m
    €104–424

  2. Bus via Karlsruhe central train station

    cheapest
    1. Take the bus from Karlsruhe central train station to Florence Villa Constanza Bus Stationbus bus N77
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    16h 5m
    €85–126

  3. Bus

    1. Take the bus from Karlsruhe Central Bus Station to Florence Villa Constanza Bus Stationbus bus
    2. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 1518 / ...
    13h 5m
    €119–163

  4. Drive  889.8 km

    1. Drive from Karlsruhe to Sienacar car 889.8 km
    8h 46m
    €145–209

  5. Train to Frankfurt, fly to Florence Peretola Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Florence Peretola Airport (FLR)plane plane FRA - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    7h 27m
    €156–368

  6. Train to Stuttgart Airport, fly to Florence Peretola Airport, train

    1. Take the train from Karlsruhe Hbf to Stuttgart Hbftrain train
    2. Fly from Stuttgart Airport (STR) to Florence Peretola Airport (FLR)plane plane STR - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    8h 53m
    €139–393

  7. Train to Frankfurt, fly to Bologna Guglielmo Marconi Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Frankfurttrain train
    2. Fly from Frankfurt (FRA) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FRA - BLQ
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4. Take the train from Firenze S.M.N. to Sienatrain train
    8h
    €138–348

  8. Train to Strasbourg International Airport, fly to Florence Peretola Airport, train

    1. Take the train from Karlsruhe Hauptbahnhof to Strasbourg Bahnhoftrain train
    2. Fly from Strasbourg International Airport (SXB) to Florence Peretola Airport (FLR)plane plane SXB - FLR
    3. Take the train from Firenze S.M.N. to Sienatrain train
    7h 14m
    €88–372

  9. Train, train to Zurich Airport, fly to Florence Peretola Airport

    1. Take the train from Karlsruhe Hauptbahnhof to Basel SBBtrain train
    2. Take the train from Basel SBB to Zürich HBtrain train
    3. Fly from Zurich Airport (ZRH) to Florence Peretola Airport (FLR)plane plane ZRH - FLR
    4. Take the train from Firenze S.M.N. to Sienatrain train
    9h 20m
    €162–530

Karlsruhe to Siena by train and bus

Calendar76Weekly Services
Duration11h 54mAverage Duration
Ticket€104Cheapest Price
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Comparing Your Travel Options

Map of how to get from Karlsruhe to Siena.ExpandLaunch map view
  • Distance: 897.2 km
  • Duration: 11h 54m

What companies run services between Karlsruhe, Germany and Siena, Italy?

You can take a bus from Karlsruhe Central Bus Station to Siena via Florence Villa Constanza Bus Station in around 13h 5m.

Airlines
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