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How to get fromKentucky to Mayo Clinicby plane, bus (Amtrak, Greyhound, Flixbus), bus, train, or car

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There are 10 ways to get from Kentucky to Mayo Clinic by plane, bus (Amtrak, Greyhound, Flixbus), bus, train, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Rochester

    best
    1. Fly from Louisville International Airport (SDF) to Rochester (RST)plane plane SDF - RST
    6h 51m
    $78–493

  2. Fly Owensboro–Daviess County Regional Airport to Rochester

    cheapest
    1. Fly from Owensboro–Daviess County Regional Airport (OWB) to Rochester (RST)plane plane OWB - RST
    9h 49m
    $77–423

  3. Bus

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    15h 30m
    $134–182

  4. Bus, train

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochesterbus bus
    19h 22m
    $371–604

  5. Drive  640.9 mi

    1. Drive from Louisville to Mayo Cliniccar car 640.9 mi
    10h 43m
    $114–164

  6. Fly Covington to Rochester

    1. Fly from Covington (CVG) to Rochester (RST)plane plane CVG - RST
    6h 55m
    $102–692

  7. Fly Covington to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Covington (CVG) to Minneapolis–Saint Paul International Airport (MSP)plane plane CVG - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 45m
    $442–1,152

  8. Fly Louisville International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Minneapolis–Saint Paul International Airport (MSP)plane plane SDF - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 57m
    $152–653

  9. Bus via Indianapolis

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the bus from Indianapolis Union Station to Chicago Bus Stationbus bus
    3. Take the bus from Chicago Bus Station to Madisonbus bus
    4. Take the bus from Madison to Rochesterbus bus
    17h 6m
    $130–224

  10. Bus, train via Madison

    1. Take the bus from Louisville, KY to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    18h 4m
    $198–344

Kentucky to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration15h 30mAverage Duration
Ticket$134Cheapest Price
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Comparing Your Travel Options

Map of how to get from Kentucky to Mayo Clinic.ExpandLaunch map view
  • Distance: 545.6 mi
  • Duration: 6h 51m

What companies run services between Kentucky, USA and Mayo Clinic, MN, USA?

Delta and American Airlines fly from Louisville International Airport (SDF) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Louisville, KY to Mayo Clinic via Chicago Union Station, Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 15h 30m.

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Want to know more about travelling around United States

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