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How to get fromKentucky to Mayo Clinicby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak, Greyhound)

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There are 10 ways to get from Kentucky to Mayo Clinic by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Amtrak, Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Louisville International Airport to Rochester

    best
    1. Fly from Louisville International Airport (SDF) to Rochester (RST)plane plane SDF - RST
    7h
    $82–433

  2. Fly Owensboro–Daviess County Regional Airport to Rochester

    cheapest
    1. Fly from Owensboro–Daviess County Regional Airport (OWB) to Rochester (RST)plane plane OWB - RST
    8h 35m
    $81–373

  3. Bus via Milwaukee

    1. Take the bus from Louisville Bus Station to Chicago Bus Stationbus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    15h 25m
    $131–216

  4. Bus, train

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    4. Take the bus from St. Paul to Rochester, MNbus bus
    19h 4m
    $241–484

  5. Drive 640.9 mi

    1. Drive from Louisville to Mayo Cliniccar car 640.9 mi
    10h 46m
    $117–169

  6. Fly Covington to Rochester

    1. Fly from Covington (CVG) to Rochester (RST)plane plane CVG - RST
    6h 36m
    $92–492

  7. Fly Louisville International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Louisville International Airport (SDF) to Minneapolis–Saint Paul International Airport (MSP)plane plane SDF - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 34m
    $154–605

  8. Fly Covington to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Covington (CVG) to Minneapolis–Saint Paul International Airport (MSP)plane plane CVG - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 26m
    $854–1,554

  9. Bus

    1. Take the bus from Louisville, KY to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    15h 44m
    $122–219

  10. Bus, train via Madison

    1. Take the bus from Louisville Bus Station to Indianapolis Union Stationbus bus
    2. Take the train from Indianapolis to Chicago Union Stationtrain train
    3. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    4. Take the bus from Madison to Rochesterbus bus
    17h 39m
    $158–304

Kentucky to Mayo Clinic by bus, train, and foot

Calendar3Weekly Services
Duration19h 4mAverage Duration
Ticket$241Cheapest Price
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Questions & Answers

Map of how to get from Kentucky to Mayo Clinic.ExpandLaunch map view
  • Distance: 545.7 mi
  • Duration: 7h

What companies run services between Kentucky, USA and Mayo Clinic, MN, USA?

United Airlines, Delta, and American Airlines fly from Louisville International Airport (SDF) to Rochester (RST) every 4 hours. Alternatively, you can take a bus from Louisville Bus Station to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 15h 25m.

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