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How to get fromKey Largo to Charlestonby shuttle, plane, bus, train, bus (Greyhound, Flixbus), or car

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There are 5 ways to get from Key Largo to Charleston by shuttle, plane, bus, train, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Shuttle to Miami International Airport, fly

    best
    1. Take a shuttle bus from Key Largo, FL to Miami, FL - International Airportshuttle bus
    2. Fly from Miami International Airport (MIA) to Charleston International Airport (CHS)plane plane MIA - CHS
    5h 37m
    $612–1,128

  2. Drive 643.4 mi

    cheapest
    1. Drive from Key Largo to Charlestoncar car 643.4 mi
    10h 59m
    $118–170

  3. Bus, train

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus Greyhound US0720s
    2. Take the train from Hollywood Amtrak Station to Charleston Amtrak Stationtrain train Silver Meteor
    16h 33m
    $268–510

  4. Bus

    1. Take the bus from Key Largo Bus Stop to Miami Airport Stationbus bus
    2. Take the bus from Miami Airport Station to Ft Lauderdale Broward Park & Ridebus bus
    3. Take the bus from Ft Lauderdale Broward Park & Ride to Savannah Bus Stationbus bus
    4. Take the bus from Savannah Bus Station to Charleston Bus Stationbus bus
    18h 48m
    $125–212

  5. Shuttle to Fort Lauderdale–Hollywood International Airport, fly

    1. Take a shuttle bus from Key Largo, FL to Fort Lauderdale, FL - International Airportshuttle bus
    2. Fly from Fort Lauderdale–Hollywood International Airport (FLL) to Charleston International Airport (CHS)plane plane FLL - CHS
    6h
    $299–1,247

Key Largo to Charleston by bus

Calendar3Weekly Buses
Duration18h 48mAverage Duration
Ticket$125Cheapest Price
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Questions & Answers

Map of how to get from Key Largo to Charleston.ExpandLaunch map view
  • Distance: 562.7 mi
  • Duration: 5h 37m

What companies run services between Key Largo, FL, USA and Charleston, SC, USA?

You can take a bus from Key Largo Bus Stop to Transit Mall via Miami Airport Station, Ft Lauderdale Broward Park & Ride, Savannah Bus Station, Charleston Bus Station, North Charleston Transit Center, N. Charleston SuperStop, and Rivers Ave / Cosgrove Ave in around 18h 48m.

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